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4-Aminopyridine Inhibits the Large-conductance Ca2+-activated K+ Channel (BKCa) Currents in Rabbit Pulmonary Arterial Smooth Muscle Cells
YoungMinBae, AeranKim, BokyungKim, Sung-IlCho, JunghwanKim, YungEEarm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.1 5 25-28 (4 pages)
we tested the hypothesis that 4-aminopyridine (4-AP) could affect the large conductance Ca2-activated K channel (BKCa) currents using perforated-patch or cell-attached configuration of patch-clamp technique in the rabbit pulmonary arterial smooth muscle. Application of 4-AP reversibly inhibited the spontaneous transient outward currents (STOCs). The reversal potential and the sensitivity to charybdotoxin indicated that the STOCs were due to the activation of BKCa. The BKCa currents... -
Relaxant Effect of 4-Aminopyridine on the Mesenteric Artery of Rat
Se-HoonKimTae-ImLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.6 4 455-461 (7 pages)
It has been well known that 4-aminopyridine (4-AP) has an excitatory effect on vascular smooth muscle due to causing membrane depolarization by blocking K-channel. However, we observed that 4-AP had an inhibitory effect on the mesenteric artery of rat. Therefore, we investigated the mechanism of 4-AP-induced vasorelaxation. The mesenteric arcuate artery and its branches were isolated and cut into ring. The ring segment was immersed in HEPES-buffered solution and its isometric tension was... -
Microwave-assisted Synthesis of Mixed Ligand Complexes of Zn(II), Cd(II) and Hg(II) Derived from 4-aminopyridine and Nitrite Ion: Spectral, Thermal and Biological Investigations
Dhaveethu. Karuthakannan, Ramachandramoorthy. Thiagarajan, Thirunavukkarasu. Kandasamy 대한화학회 대한화학회지 11 Pages
대한화학회 대한화학회지 2013, Vol.57 No.3 341-351 (11 pages)
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유드라짓과 알긴산 나트륨 매트릭스를 이용한 4-Aminopyridine의 서방성 제제설계
김정수, 김동우, 이계원, 지웅길, Kim. Jeong-Soo, Kim. Dong-Woo, Lee. Gye-Won, Jee. Ung-Kil 한국약제학회 藥劑學會誌 8 Pages
한국약제학회 藥劑學會誌 2005, Vol.35 No.6 453-460 (8 pages)
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Alteration of 4-Aminopyridine-Sensitive, Voltage-Dependent K+- Channel in Arterial Smooth Muscle Cells of One-Kidney, One-Clip Goldblatt Hypertensive Rats
Hoe-SukKim, Se-HoonKim, Byeong-HwaJeon, Seok-JongChang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.5 7 385-391 (7 pages)
Using the patch-clamp technique, we investigated the alteration of 4-aminopyridine(4-AP)-sensitive, voltage-dependent K channel (Kv) in the mesenteric arterial smooth muscle cell (MASMC) of renovascular hypertensive model, one-kidney one-clip Goldblatt hypertensive rat (GBH). To isolate KV current, internal pipette solution contained 5 mM ATP and 10 mM EGTA. Under these condition, MASMC was depolarized by 4-AP, but charybdotoxin did not affect membrane potential. Membrane potential of... -
Inhibition of voltage-dependent K+ current in rabbit coronary arterial smooth muscle cells by the class Ic antiarrhythmic drug propafenone
Jin Ryeol An, Hongliang Li, Mi Seon Seo, Won Sun Park 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.5 13 597-605 (9 pages)
a dose-dependent manner, with an apparent IC50 value of 5.04±1.05 μM and a Hill coefficient of 0.78±0.06. The application of propafenone had no significant effect on the steady-state activation and inactivation curves, indicating that propafenone did not affect the voltage-sensitivity of Kv channels. The application of train pulses at frequencies of 1 or 2 Hz progressively increased the propafenone-induced inhibition of the Kv current. Furthermore, the inactivation recovery time constant was... -
Myometrial relaxation of mice via expression of two pore domain acid sensitive K+ (TASK-2) channels
Kyu-SangKyeong, SeungHwaHong, YoungChulKim, *, WoongChoi, SunChulMyung, MooYeolLee, RaYoungYou, ChanHyungKim, SoYeonKwon, HikaruSuzuki, Yeo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.5 13 547-556 (10 pages)
patch clamp technique were used to verify TASK conductance in murine myometrium. Western blot and immunehistochemical study under confocal microscopy were used to investigate molecular identity of TASK channel. In this study, we showed that TEA and 4-AP insensitive non‐inactivating outward K+ current (NIOK) may be responsible for the quiescence of murine pregnant longitudinal myometrium. The characteristics of NIOK coincided with twopore domain acid‐sensing K+ channels (TASK-2). NIOK...
