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01.

Inhibition of voltage-dependent K+ current in rabbit coronary arterial smooth muscle cells by the class Ic antiarrhythmic drug propafenone

Jin Ryeol An, Hongliang Li, Mi Seon Seo, Won Sun Park 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.5 13 597-605 (9 pages)

Jin Ryeol An, Hongliang Li, Mi Seon Seo, Won Sun Park 저
...
- 3,000원
In this study, we demonstrated the inhibitory effect of the Class Ic antiarrhythmic agent propafenone on voltage-dependent K+ (Kv) channels using freshly isolated coronary artery smooth muscle cells from rabbits. The Kv current amplitude was progressively inhibited by propafenone in a dose-dependent manner, with an apparent IC50 value of 5.04±1.05 μM and a Hill coefficient of 0.78±0.06. The application of propafenone had no significant effect on the steady-state activation and inactivation...
02.

Lamotrigine, an antiepileptic drug, inhibits 5-HT3 receptor currents in NCB-20 neuroblastoma cells

KiJungKim, SeungHyunJeun, Ki-WugSung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.2 4 169-177 (9 pages)

KiJungKim, SeungHyunJeun, Ki-WugSung 저
...
- 3,000원
Lamotrigine is an antiepileptic drug widely used to treat epileptic seizures. Using whole-cell voltage clamp recordings in combination with a fast drug application approach, we investigated the effects of lamotrigine on 5-hydroxytryptamine (5-HT)3 receptors in NCB-20 neuroblastoma cells. Coapplication of lamotrigine (1~300 μM) resulted in a concentration-dependent reduction in peak amplitude of currents induced by 3 μM of 5-HT for an IC50 value of 28.2±3.6 μM with a Hill coefficient of...
03.

Modern Methods for Analysis of Antiepileptic Drugs in the Biological Fluids for Pharmacokinetics, Bioequivalence and Therapeutic Drug Monitoring

JuseopKang, Yoo-SinPark, Shin-HeeKim, Sang-HyunKim, Min-YoungJun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 16 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.2 1 67-82 (16 pages)

JuseopKang, Yoo-SinPark, Shin-HeeKim, Sang-HyunKim, Min-YoungJun 저
...
- 4,500원
these drugs. These drug concentrations in biological fluids serve as surrogate markers and can be used to guide or target drug dosing. Because early studies demonstrated clinical and/or electroencephalographic correlations with serum concentrations of several AEDs, It has been almost 50 years since clinicians started using plasma concentrations of AEDs to optimize pharmacotherapy in patients with epilepsy. Therefore, validated analytical method for concentrations of AEDs in biological fluids is...
04.

Effects of adolescent substance abuse on executive function, personality, and behavior -An anlaysis of juvenile reformatory students-

MORIGUCHI Yukako, OISHI Naoya, MURAI Toshiya, FUKUI Hiroki, FUKUYAMA Hidenao 아시아아동지원학회 아시아아동지원연구 9 Pages

아시아아동지원학회 아시아아동지원연구 2011, 제 2권 7 55-63 (9 pages)

MORIGUCHI Yukako, OISHI Naoya, MURAI Toshiya, FUKUI Hiroki, FUKUYAMA Hidenao 저
- 3,000원
a crime, including drug offenses, increases in adolescents. Along with the increase in drug offenses, the majority of those in medical reformatories for juvenile offenders are youth8 with mental illness, rather than those with physical illness. A decline in executive function is one of the commonly reported neuropsychological traits of substance dependents; however. most studies examine substance dependence in adults. and there have been only a small number of studies on adolescent substance...
05.

Screening of multiple drugs of abuse and metabolites in urine using LC/MS/MS with polarity switching electrospray ionization

Shin. Miok, Ji. Dajeong, Kang. Soyoung, Yang. Wonkyung, Choi. Hwakyung, Lee. Sooyeun 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 13 Pages

대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 2014, Vol.37 No.6 760-772 (13 pages)

Shin. Miok, Ji. Dajeong, Kang. Soyoung, Yang. Wonkyung, Choi. Hwakyung, Lee. Sooyeun 저

이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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06.

Antimicrobial Resistance of E. coli isolated from Chicken during 2014-2016 in South Korea

Hye Jin Lee, Byung Kook Choi, Ok Mi Jeong, Chun Tae Lim, So Youn Youn, Byung Woo Jeon, Jun Hyeop Jeong, Su jung Kim, Hee Soo Lee, Min Su 대한수의학회 대한수의학회 학술대회발표집 2 Pages

대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 181 309-310 (2 pages)

Hye Jin Lee, Byung Kook Choi, Ok Mi Jeong, Chun Tae Lim, So Youn Youn, Byung Woo Jeon, Jun Hyeop Jeong, Su jung Kim, Hee Soo Lee, Min Su 저
...
- 무료
07.

Evaluation of effects of olfactory and auditory stimulation on separation anxiety by salivary cortisol measurement in dogs

Yoon-Joo Shin, Nam-Shik Shin* 대한수의학회 Journal of Veterinary Science 6 Pages

대한수의학회 Journal of Veterinary Science 2016, 제 17권 제 2호 4 153-158 (6 pages)

Yoon-Joo Shin, Nam-Shik Shin* 저
...
- 3,000원
Separation anxiety (SA) is a serious behavioral problem in dogs. In this study, salivary cortisol was studied to determine if the owner’s odor or voice could reduce SA in dogs. Twenty-eight dogs with SA were divided into three groups: group 1 (control), group 2 (with owner’s clothes during the separation period; SP) and group 3 (a recording of the owner’s voice was played during SP). The dog’s saliva was collected after the owner and their dog were in the experimental room for 5 min (PRE)....
08.

Distribution, quantitative load and characterization of Salmonella associated with swine farms in upper-northern Thailand

Pakpoom Tadee, Kittipong Kumpapong, Danai Sinthuya, Panuwat Yamsakul, Nipa Chokesajjawatee, Supachai Nuanualsuwan, Suchawan Porn 대한수의학회 Journal of Veterinary Science 8 Pages

대한수의학회 Journal of Veterinary Science 2014, 제 15권 제 2호 20 327-334 (8 pages)

Pakpoom Tadee, Kittipong Kumpapong, Danai Sinthuya, Panuwat Yamsakul, Nipa Chokesajjawatee, Supachai Nuanualsuwan, Suchawan Porn 저
...
- 3,000원
This study was conducted to analyze the prevalence and quantitative loads of Salmonella spp. on pig farms in Chiang Mai, Lamphun, Thailand to assess loading levels before slaughtering. The serotype diversity, antimicrobial-resistance pattern and pulse-field type of Salmonella spp. were also characterized to assess the dynamic propagation of the pathogen. The Salmonella-positive prevalence was 246/805 (30.56%), and the quantitative loads varied from 1.48∼4.04 Log10MPN/g, with a mean ± standard...
09.

Betulinic acid prevents alcohol-induced liver damage by improving the antioxidant system in mice

Jine Yi*, Wei Xia, Jianping Wu, Liyun Yuan, Jing Wu, Di Tu, Jun Fang, Zhuliang Tan* 대한수의학회 Journal of Veterinary Science 8 Pages

대한수의학회 Journal of Veterinary Science 2014, 제 15권 제 1호 16 141-148 (8 pages)

Jine Yi*, Wei Xia, Jianping Wu, Liyun Yuan, Jing Wu, Di Tu, Jun Fang, Zhuliang Tan* 저
...
- 3,000원
Betulinic acid (BA), a pentacyclic lupane-type triterpene, has a wide range of bioactivities. The main objective of this work was to evaluate the hepatoprotective activity of BA and the potential mechanism underlying the ability of this compound to prevent liver damage induced by alcohol in vivo. Mice were given oral doses of BA (0.25, 0.5, and 1.0 mg/kg) daily for 14 days, and induced liver injury by feeding 50% alcohol orally at the dosage of 10 ml/kg after 1 h last administration of BA. BA...
10.

원저 : 건강한 가축에서 분리한 Escherichia coli의 항생제 내성 조사(2010~2012년)

임숙경, 남향미, 문동찬, 장금찬, 정석찬 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 7 Pages

대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2014, 제 54권 제 3호 1 131-137 (7 pages)

임숙경, 남향미, 문동찬, 장금찬, 정석찬 저
...
- 3,000원

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