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전체 선택해제
총 313건 검색
본문검색 결과만 보기
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Insulin Like Growth Factor Binding Protein-5 Regulates Excessive Vascular Smooth Muscle Cell Proliferation in Spontaneously Hypertensive Rats via ERK 1/2 Phosphorylation
DongHyupLee, JungEunKim, YoungJinKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.2 7 157-162 (6 pages)
addition, recombinant IGFBP-5 significantly up-regulated ERK1/2 phosphorylation in the VSMCs of WKY as much as those of SHR. Concurrent treatment with the MEK1/2 inhibitors, PD98059 or U0126 completely inhibited recombinant IGFBP-5-induced VSMC proliferation in WKY, while concurrent treatment with the phosphatidylinositol-3 kinase inhibitor, LY294002, had no effect. Furthermore, knockdown with IGFBP-5 siRNA inhibited ERK1/2 phosphorylation in VSMC of SHR. These results suggest that IGFBP-5 plays... -
RGS Protein Specificity Towards Gq- and Gi/o-Mediated ERK 1/2 and Akt Activation, in vitro
Anger. Thomas, Klintworth. Nils, Stumpf. Christian, Daniel. Werner G., Mende. Ulrike, Garlichs. Christoph D. 생화학분자생물학회 Journal of biochemistry and molecular biology 12 Pages
생화학분자생물학회 Journal of biochemistry and molecular biology 2007, Vol.40 No.6 899-910 (12 pages)
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Mycobacteria-induced Interleukin-12 Expression by Human Monocyte-derived Macrophages Is Negatively Regulated by Phosphatidylinositol 3-kinase and ERK 1/2 Pathways
Yang. Chul-Su, Lee. Ji-Sook, Song. Chang-Hwa, Jung. Saet-Byel, Lee. Kil-Soo, Shin. A-Rum, Kim. Hwa-Jung, Park. Jeong-Kyu, Paik. Tae-Hyun 대한미생물학회 Journal of bacteriology and virology : JBV 10 Pages
대한미생물학회 Journal of bacteriology and virology : JBV 2005, Vol.35 No.3 239-248 (10 pages)
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High Glucose Induces Connective Tissue Growth Factor Expression and Extracellular Matrix Accumulation in Rat Aorta Vascular Smooth Muscle Cells Via Extracellular Signal-Regulated Kinase 1/2
YuMiHa, DongHyupLee, MinaKim, YoungJinKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.4 8 307-314 (8 pages)
high glucose-stimulated VSMCs. Furthermore, knockdown with ERK1/2 MAPK siRNA resulted in significantly down regulated of CTGF production, ECM components accumulation and cell proliferation in high glucose-stimulated VSMCs. Finally, ERK1/2 signaling regulated Egr-1 protein expression and treatment with recombinant CTGF reversed the Egr-1 expression in high glucose-induced VSMCs. It is conceivable that ERK1/2 MAPK signaling pathway plays an important role in regulating CTGF expression and suggests... -
Cobalt Chloride-induced Apoptosis and Extracellular Signal-regulated Protein Kinase 1/2 Activation in Rat C6 Glioma Cells
Yang. Seung-Ju, Pyen. Jhin-Soo, Lee. In-Soo, Lee. Hye-Young, Kim. Young-Kwon, Kim. Tae-Ue 생화학분자생물학회 Journal of biochemistry and molecular biology 7 Pages
생화학분자생물학회 Journal of biochemistry and molecular biology 2004, Vol.37 No.4 480-486 (7 pages)
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Porphyromonas gingivalis, Periodontal Pathogen, Lipopolysaccharide Induces Angiogenesis via Extracellular Signal-Regulated Kinase 1/2 Activation in Human Vascular Endothelial Cells
Koo. Tae-Hyeon, Jun. Hyung-Oh, Bae. Soo-Kyung, Kim. Su-Ryun, Moon. Chang-Pyo, Jeong. Seong-Kyoon, Kim. Woo-Sik, Kim. Gyoo-Cheon, Jang. H 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 9 Pages
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 2007, Vol.30 No.1 34-42 (9 pages)
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cAMP induction by ouabain promotes endothelin-1 secretion via MAPK/ERK signaling in beating rabbit atria
Li-qunPeng, PingLi, Qiu-liZhang, LanHong, Li-pingLiu, XunCui, Bai-riCui 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.1 2 9-14 (6 pages)
(0.5 μmol/L) markedly increased atrial ET-1 secretion, which was blocked by H-89 and by PD98059 (30 μmol/L), an inhibitor of extracellular-signal-regulated kinase (ERK) without changing ouabain-induced atrial dynamics. Our results demonstrated that ouabain increases atrial cAMP levels and promotes atrial ET-1 secretion via the mitogen-activated protein kinase (MAPK)/ERK signaling pathway. These findings may explain the development of cardiac hypertrophy in response to digitalis-like compounds. -
FSL-1, a Toll-like Receptor 2/6 Agonist, Induces Expression of Interleukin-1α in the Presence of 27-hydroxycholesterol
WeonHeo, Sun-MiKim, Seong-KugEo, Byung-YongRhim, KoanhoiKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.6 5 475-480 (6 pages)
underlying the expression of TLR6 and IL-1α. Treatment with Akt inhibitor IV or U0126 resulted in significantly attenuated expression of TLR6 and IL-1α induced by 27OHChol and 27OHChol plus FSL-1, respectively. In addition, treatment with LY294002, SB202190, or SP600125 resulted in significantly attenuated secretion of IL-1α. These results indicate that 27OHChol can induce inflammation by augmentation of TLR6-mediated production of IL-1α in monocytic cells via multiple signaling pathways. -
HIV-1 Tat Protein-dependent Cytotoxicity is Attenated by 15-deoxy-$Delta^{12,14}$-Prostaglandin J2 in Rat Hippocampal Slices: Involvement of the ERK1/2 Signaling Pathway
Lee. Eun Ok, Yang. Ji Hye, Kim. Ju Hyun, Woo. So Youn, Chong. Young Hae 대한미생물학회 Journal of bacteriology and virology : JBV 9 Pages
대한미생물학회 Journal of bacteriology and virology : JBV 2013, Vol.43 No.1 45-53 (9 pages)
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Salicylate Regulates Cyclooxygenase-2 Expression through ERK and Subsequent NF-κB Activation in Osteoblasts
Han-JungChae, Jun-KiLee, Joung-OukByun, Soo-WanChae, Hyung-RyongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.4 8 239-246 (8 pages)
the ERK pathway with selective inhibitor, PD098059, blocked cytokine-induced COX-2 expression and PGE2 release. Salicylate treatment inhibited COX-2 expression induced by TNF-α/IFN-γ and regulated the activation of ERK, IKK and IκB degradation and subsequent NF-κB activation in MC3T3E1 osteoblasts. Furthermore, antioxidants such as catalase, N-acetyl-cysteine or reduced glutathione attenuated COX-2 expression in combined cytokines-treated cells, and also inhibited the activation of ERK, IKK...
