자료유형
전체 선택해제
총 10건 검색
본문검색 결과만 보기
-
Radicicol Inhibits iNOS Expression in Cytokine-Stimulated Pancreatic Beta Cells
ChaKyungYoun, SeonJooPark., MeiHongLi, MinYoungLee, KunYeongLee, ManJinCha, OkHyeunKim, HoJinYou, InYoupChang, SangPilYoon, YoungJinJeon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.4 9 315-320 (6 pages)
Here, we show that radicicol, a fungal antibiotic, resulted in marked inhibition of inducible nitric oxide synthase (iNOS) transcription by the pancreatic beta cell line MIN6N8a in response to cytokine mixture (CM: TNF-Ձ, IFN-Ճ, and IL-1Ղ). Treatment of MIN6N8a cells with radicicol inhibited CM-stimulated activation of NF-ՊB/Rel, which plays a critical role in iNOS transcription, in a dose-related manner. Nitrite production in the presence of PD98059, a specific inhibitor... -
Development of a Selective Medium for the Fungal Pathogen Cylindrocarpon destructans Using Radicicol
한국식물병리학회 The Plant Pathology Journal 5 Pages
한국식물병리학회 The Plant Pathology Journal 2014, 30권 4호 11 432-436 (5 pages)
a selective medium for C. destructans using radicicol produced by this fungus. Supplementing 50 mg/L of radicicol to medium inhibited the mycelia growth of other fungi including Botrytis cinerea, Rhizoctonia solani and Alternaria panax, but did not affect the growth of C. destructans. In addition, conidia germination of other fungal species except for C. destructans was inhibited in submerged culture supplemented with radicicol. This medium provides a very efficient tool for isolating C.... -
Inhibition of p65 Nuclear Translocation by Radicicol, Heat Shock Protein Inhibitor
Kim. Sang-Gyu, Jeon. Young-Jin, Lee. Seog-Ki 한국독성학회 Journal of toxicology and public health : an official journal of the Korean Society of Toxicology 6 Pages
한국독성학회 Journal of toxicology and public health : an official journal of the Korean Society of Toxicology 2005, Vol.21 No.4 285-290 (6 pages)
-
Radicicol이 신경세포에서 베타 아밀로이드 전구단백질의 대사에 미치는 영향
임재윤, 이일화, 이경아, 공두균, 최부진, 이충수, 은재순, Leem. Jae-Yoon, Lee. Ri-Hua, Lee. Kyung-A, Gong. Du-Gyun, Choi. Bu-Jin, Lee. Choong-Soo, Eun. Jae-Soon 대한약학회 약학회지 6 Pages
대한약학회 약학회지 2007, Vol.51 No.4 264-269 (6 pages)
-
Inhibition of ERK1/2 by silymarin in mouse mesangial cells
ChaKyungYoun, SungIlCho, MinYoungLee, YoungJinJeon, SeogKiLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.1 14 117-124 (8 pages)
The present study aimed to show that pro-inflammatory cytokines [tumor necrosis factor (TNF)-α, interferon (IFN)-γ, and interleukin (IL)-1β] synergistically induce the production of nitric oxide (NO) production in mouse mesangial cells, which play an important role in inflammatory glomerular injury. We also found that co-treatment with cytokines at low doses (TNF-α; 5 ng/ml, IFN-γ; 5 ng/ml, and IL-1β; 1.25 U/ml) synergistically induced NO production, whereas treatment with each cytokine... -
Silymarin Inhibits Morphological Changes in LPS-Stimulated Macrophages by Blocking NF-κB Pathway
EunJeongKim, MinYoungLee, YoungJinJeon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.3 4 211-218 (8 pages)
The present study showed that silymarin, a polyphenolic flavonoid isolated from milk thistle (Silybum marianum), inhibited lipopolysaccharide (LPS)-induced morphological changes in the mouse RAW264.7 macrophage cell line. We also showed that silymarin inhibited the nuclear translocation and transactivation activities of nuclear factor-kappa B (NF-κB), which is important for macrophage activation-associated changes in cell morphology and gene expression of inflammatory cytokines. BAY- 11-7085,... -
Synergistic Induction of iNOS by IFN-g and Glycoprotein Isolated from Dioscorea batatas
PhamThiThuHuong, MinYoungLee, KunYeongLee, InYoupChang, SeogKiLee, SangPilYoon, Dong-CheolLee, YoungJinJeon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.6 9 431-436 (6 pages)
Dioscorea species continue to be used in traditional Chinese medicine, and represent a major source of steroid precursors for conventional medicine. In the previous study, We isolated glycoprotein (GDB) from Dioscorea batatas, characterized, and demonstrated immunostimulating activity in C57BL/6 mice. The aim of this study was to investigate the mechanism whereby GDB activates macrophages. Macrophages activation by GDB was investigated by analyzing the effects of GDB on nitric oxide (NO)... -
Characterization and Immunopotentiating Effects of the Glycoprotein Isolated from Dioscorea Batatas
PhamThiThuHuong, Chan-HoLee, MeiHongLi, MinYoungLee, Joon-KiKim, Sun-MeeLee, Jong-HeumSeon, Dong-CheolLee, YoungJinJeon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.2 5 101-106 (6 pages)
We demonstrate that glycoprotein isolated from Dioscorea batatas (GDB) has immunostimulatory effects including macrophage activation. Analysis of infiltration of inflammatory cells into peritoneal cavity showed GDB treatment significantly increased the recruitment of macrophages, lymphocytes, neutrophils, and monocytes into the peritoneal cavity. Treatment of spleen cells isolated from C57BL/6 mice with GDB significantly increased the proliferation of B cells and T cells induced by LPS and ConA,... -
Magnolol Inhibits LPS-induced NF-κB/Rel Activation by Blocking p38 Kinase in Murine Macrophages
MeiHongLi, GuganKothan, SeungJooCho, PhamThiThuHuong, YongHaiNan, KunYeongLee, SongYubShin, SungSuYea, YoungJinJeon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.6 1 353-358 (6 pages)
This study demonstrates the ability of magnolol, a hydroxylated biphenyl compound isolated from Magnolia officinalis, to inhibit LPS-induced expression of iNOS gene and activation of NF-ՊB/Rel in RAW 264.7 cells. Immunohisto-chemical staining of iNOS and Western blot analysis showed magnolol to inhibit iNOS gene expression. Reporter gene assay and electrophoretic mobility shift assay showed that magnolol inhibited NF-ՊB/Rel transcriptional activation and DNA binding, respectively.... -
Diagnosis of Cylindrocarpon destructans Using Enzyme-Linked Immunosorbent Assay
Taiying Li, Sungyeon Ji, Boknam Jung, Bo Yeon Kim, Kwang Sik Lee, Mun Won Seo, Sung Woo Lee, Jungkwan Lee, Seung-Ho Lee 한국식물병리학회 식물병연구 5 Pages
한국식물병리학회 식물병연구 2019, 25권 3호 5 131-135 (5 pages)
Cylindrocarpon destructans causes ginseng root rot and produces radicicol that has an antifungal effect. In this study, we developed a method to detect this fungus using enzyme-linked immunosorbent assay (ELISA). Secreted proteins of C. destructans were used as antigens to obtain C. destructans-specific IgG from mouse. Out of 318 monoclonal antibodies generated from mouse, two antibodies (Cd7-2-2 and Cd7-2-10) showed highest specificity and sensitivity. Indirect ELISA using both antigens...
