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Angiogenic Effects of Spheroid Formation from Mesenchymal Stem Cells
Mi Jeong Park, Jeong Su Byeon, Na Yeon Gu, Jienny Lee, In Soo Cho, Sang Ho Cha 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 321 367-368 (2 pages)
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Gintonin, an exogenous ginseng-derived LPA receptor ligand, promotes corneal wound healing
Hyeon-Joong Kim, Joon Young Kim, Byung-Hwan Lee, Sun-Hye Choi, Hyewon Rhim, Hyoung-Chun Kim, Seoung-Yob Ahn, Soon-Wuk Jeong, Min 대한수의학회 Journal of Veterinary Science 11 Pages
대한수의학회 Journal of Veterinary Science 2017, 제 18권 제 3호 16 387-397 (11 pages)
Ginseng gintonin is an exogenous ligand of lysophosphatidic acid (LPA) receptors. Accumulating evidence shows LPA helps in rapid recovery of corneal damage. The aim of this study was to evaluate the therapeutic efficacy of gintonin in a rabbit model of corneal damage. We investigated the signal transduction pathway of gintonin in human corneal epithelium (HCE) cells to elucidate the underlying molecular mechanism. We next evaluated the therapeutic effects of gintonin, using a rabbit model of... -
Elucidating the role of ApxI in hemolysis and cellular damage by using a novel apxIA mutant of Actinobacillus pleuropneumoniae serotype 10
Nai-Yun Chang, Zeng-Weng Chen, Ter-Hsin Chen, Jiunn-Wang Liao, Cheng-Chung Lin, Maw-Sheng Chien, Wei-Cheng Lee, Jiunn-Horng Lin, 대한수의학회 Journal of Veterinary Science 9 Pages
대한수의학회 Journal of Veterinary Science 2014, 제 15권 제 1호 9 81-89 (9 pages)
Exotoxins produced by Actinobacillus (A.) pleuropneumoniae (Apx) play major roles in the pathogenesis of pleuropneumonia in swine. This study investigated the role of ApxI in hemolysis and cellular damage using a novel apxIA mutant, ApxIA336, which was developed from the parental strain A. pleuropneumoniae serotype 10 that produces only ApxI in vitro. The genotype of ApxIA336 was confirmed by PCR, Southern blotting, and gene sequencing. Exotoxin preparation derived from ApxIA336 was analyzed for... -
The TREK2 Channel Is Involved in the Proliferation of 253J Cell, a Human Bladder Carcinoma Cell
Kyung-SunPark, MinHoHan, HeeKyungJang, Kyung-AKim, Eun-JongCha, Wun-JaeKim, YungHyunChoi, YangmiKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.6 6 511-516 (6 pages)
Bladder cancer is the seventh most common cancer in men that smoke, and the incidence of disease increases with age. The mechanism of occurrence has not yet been established. Potassium channels have been linked with cell proliferation. Some two-pore domain K＋ channels (K2P), such as TASK3 and TREK1, have recently been shown to be overexpressed in cancer cells. Here we focused on the relationship between cell growth and the mechanosensitive K2P channel, TREK2, in the human bladder cancer cell... -
Quercetin-induced Growth Inhibition in Human Bladder Cancer Cells Is Associated with an Increase in Ca2＋-activated K＋ Channels
YangmiKim, Wun-JaeKim, , Eun-JongCha 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.5 5 279-284 (6 pages)
Quercetin (3,3',4',5,7-pentahydroxyflavone) is an attractive therapeutic flavonoid for cancer treatment because of its beneficial properties including apoptotic, antioxidant, and antiproliferative effects on cancer cells. However, the exact mechanism of action of quercetin on ion channel modulation is poorly understood in bladder cancer 253J cells. In this study, we demonstrated that large conductance Ca2＋- activated K＋ (BKCa) or MaxiK channels were functionally expressed in 253J cells, and... -
Tetrahydrobiopterin Inhibits PDGF-stimulated Migration and Proliferation in Rat Aortic Smooth Muscle Cells via the Nitric Oxide Synthase-independent Pathway
XiaowenJiang, BokyungKim, HaiyueLin, Chang-KwonLee, JunghwanKim, HyunKang, PilyoungLee, SeungHyoJung, HwanMyungLee, Kyung-JongWon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.3 10 177-183 (7 pages)
a 5-bromo-2'-deoxyuridine incorporation assay, respectively, and these results were confirmed with an ex vivo aortic sprout assay. Cell viability was examined by 2,3-bis [2-methoxy- 4-nitro-5-sulfophenyl]-2H-tetrazolium-5-carboxanilide assays. BH4 and BH2 decreased PDGF-BB- induced cell migration and proliferation in a dose-dependent manner. The inhibition of cell migration and proliferation by BH4 and BH2 was not affected by pretreatment with NG-nitro-L-arginine methyl ester, a NOS inhibitor.... -
Olibanum Extract Inhibits Vascular Smooth Muscle Cell Migration and Proliferation in Response to Platelet-Derived Growth Factor
Ok-ByungChoi, Joo-HoonPark, YeJinLee, Chang-KwonLee, Kyung-JongWon, JunghwanKim, HwanMyungLee, BokyungKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.2 6 107-114 (8 pages)
Olibanum (Boswellia serrata) has been shown to have anti-inflammatory, anti-arthritic and anti- cancer effects. This study determined the role of a water extract of olibanum in platelet-derived growth factor (PDGF)-stimulated proliferation and migration of rat aortic smooth muscle cells (RASMCs). PDGF-BB induced the migration and proliferation of RASMCs that were inhibited by olibanum extract in a dose-dependent manner. The PDGF-BB-increased phosphorylation of p38 mitogen-activated protein... -
Inhibition of Proliferation by Anti-microbial Peptide Isolated from Pediococcus pentosaceus and Lactobacillus spp. in Colon Cancer Cell Line (HT-29, SW 480 and Caco-2)
박소희, 김윤아, 정명준, 강병용, 하남주, Park. So-Hee, Kim. Yun-A, Chung. Myung-Jun, Kang. Byung-Yong, Ha. Nam-Joo 환경독성보건학회 환경독성학회지 7 Pages
환경독성보건학회 환경독성학회지 2007, Vol.22 No.1 65-71 (7 pages)
수 있는 지를 분석하고자 하였다. XTT assay는 safelaf과 lactopad가 HT-29, SW 480 및 Caco-2의 성장을 억제하는 것으로 나타났으며, 특히, 이들 peptide들을 72시간동안 처리했을 때 나타나는 항암효과는 $3.1{sim}100mg/mL$의 농도범위에서 유의한 결과를 나타내었으며, 분석한 농도 범위에서 용량 의존적인 방식으로 더 강한 효과를 나타내었다. RAW 264.7 세포주는 cytokine인 tumor-necrosis factor(TNF-${alpha}$)의 생성에 미치는 이들 peptide들의 효과를 조사하기 위한 대식세포의 모델로써 이용되었다. RAW 264.7 세포주에서... -
전남 농공단지 폐수처리장 방류수의 화학적/생물학적 독성평가
이문희, 최익창, 한상국, Lee. Moon-Hee, Choi. Ik-Chang, Han. Sang-Kuk 해양환경안전학회 海洋環境安全學會誌 7 Pages
해양환경안전학회 海洋環境安全學會誌 2008, Vol.14 No.4 267-273 (7 pages)
폐수처리장을 선정하였다. 본 연구에서 GC-Ion trap MS로 300종의 일반적인 화학물질을 ppt수준에서 검출할 수 있는 방법을 이용하여 분석하였다. 농공폐수처리방류수에서 검출된 주요 유기오염물질은 농약류, CH구조의 방향족, CHO구조의 프탈레이트류, 그리고 CHO(N) 구조의 아로메틱 아민류였다. 또한 diethylphthalate를 포함한 17종의 내분비계장애물질이 검출되었다. XTT assay를 이용한 세포독성 결과는 TV로 나타냈으며, 그들의 세포독성은 A지점에서 27.2, D지점에서 24.4로 가장 높게 나타났다. 한편 화학적 분석 결과와...
