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The Protective Effect of Melatonin Administration against Adriamycin-induced Cardiotoxicity in Rats
JinHan, ChungheeKim, NariKim, JuheePark, YoungchurlYang, EuiyongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.4 6 333-342 (10 pages)
stimulating the immune system, and acting as an antioxidant and radical scavenging effects. In the present study, we evaluated the effect of melatonin administration on adriamycin-induced cardiotoxicity in rat. Heart slices were prepared using a Stadie-Riggs microtome for the measurement of malondialdehyde (MDA) content used as an index of lipid peroxidation and lactate dehydrogenase (LDH) release as an indicator of lethal cell injury. Serious adriamycin-induced lethality was observed in rat by... -
Effect of the Inhibition of PLA2 on Oxidative Lung Injury Induced by Interleukin-1
YoungManLee, HyunGugCho, Yoon-YubPark, Jong-KiKim, YoonJeongLee, Won-HarkPark, TeoanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.5 10 617-628 (12 pages)
In order to understand the pathogenetic mechanism of adult respiratory distress syndrome (ARDS), the role of phospholipase A2 (PLA2) in association with oxidative stress was investigated in rats. Interleukin-1 (IL-1, 50 ㄍg/rat) was used to induce acute lung injury by neutrophilic respiratory burst. Five hours after IL-1 insufflation into trachea, microvascular integrity was disrupted, and protein leakage into the alveolar lumen was followed. An infiltration of neutrophils was... -
돼지고기와 닭고기 지방산화에 대한 인삼의 효과
전기홍, 이무하, 김영붕, Jeon. Ki-Hong, Lee. Moo-Ha, Kim. Young-Boong 한국식품과학회 한국식품과학회지 4 Pages
한국식품과학회 한국식품과학회지 1992, Vol.24 No.1 7-10 (4 pages)
인삼의 육류제품에서의 사용증진을 검토하고자 항산화효과를 pH5.6에서 조사하였다. 인삼분말을 돼지고기와 닭고기에 각각 첨가하였을 때 10% 수준까지 첨가수준이 증가할 수록 항산화 효과가 증가하였으나 지방산화 억제폭은 첨가수준 증가에 따라 감소하였다. 시료에 인삼을 물 추출물, 에탄올 추출물 및 추출박으로 분획하여 첨가하였을 때 물 추출물과 추출박의 첨가는 지방산화를 억제하였으나 첨가 수준의 증가에 따른 항산화 효과는 뚜렷하지 않았다. 한편 에탄올 추출물을 시료에 첨가하였을 때는 돈육에서는 항산화 효과가...
