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전체 선택해제
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Upregulation of death receptor 5 mediated by telmisartan enhances TRAIL-mediated apoptosis via inhibition of autophagy flux in lung cancer
Mohammad Rasheduzzaman, Jeong Min Hong, Uddin Nazim, Hong hua Yin, You Jin Lee, Jae Won Seol, Sang Youel Park 대한수의학회 대한수의학회 학술대회발표집 1 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 233 337-337 (1 pages)
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Upregulation of Hypoxia-inducible factor-1a in Calbindin-D9k Knockout mice
Bonn Lee, Chang-hwan Ahn, Eui Bae Jeung 대한수의학회 대한수의학회 학술대회발표집 1 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 191 315-315 (1 pages)
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MDL-12330A potentiates TRAIL-induced apoptosis in gastric cancer cells through CHOP-mediated DR5 upregulation
Sung-ChulLimSongIyHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.4 5 397-405 (9 pages)
death whereas at concentrations greater than 20 μM, it increased non-apoptotic cell death. The induction of apoptosis was at least partially regulated by CHOP-mediated DR5 upregulation, as detected by immunoblotting and gene interference assays. More importantly, low concentrations of MDL-12330A effectively enhanced recombinant human tumor necrosis factor (TNF)-related apoptosis-inducing ligand (rhTRAIL)-induced apoptosis and clonogenicity in these gastric cancer cells. This study demonstrates... -
High fat diet confers vascular hyper-contractility against angiotensin II through upregulation of MLCK and CPI-17
JeeInKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.1 12 99-106 (8 pages)
Obesity is a critical risk factor for the hypertension. Although angiotensin II (Ang II) in obese individuals is known to be upregulated in obesity-induced hypertension, direct evidence that explains the underlying mechanism for increased vascular tone and consequent increase in blood pressure (BP) is largely unknown. The purpose of this study is to investigate the novel mechanism underlying Ang II-induced hyper-contractility and hypertension in obese rats. Eight-week old male Sprague-Dawley... -
Genipin Selectively Inhibits TNF-α-activated VCAM-1 But Not ICAM-1 Expression by Upregulation of PPAR-γ in Human Endothelial Cells
JungSeokHwa, LidiyaMun, HyeJungKim, HanGeukSeo, JaeHeunLee, JongHwanKwak, Dong-UngLee, KiChurlChang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.3 6 157-162 (6 pages)
Vascular inflammation process has been suggested to be an important risk factor in the development of atherosclerosis. Recently we reported that induction of peroxisome proliferator-activated receptor-Ճ (PPAR-Ճ) selectively inhibits vascular cell adhesion molecule-1 (VCAM-1) but not intercellular cell adhesion molecule-1 (ICAM-1) in tumor necrosis factor (TNF)-Ձ-activated human umbilical vein endothelial cells (HUVEC). In this study, we investigated whether genipin inhibits... -
Knockdown of RCAN1.4 Increases Susceptibility to FAS-mediated and DNA-damage-induced Apoptosis by Upregulation of p53 Expression
YoungSunKim, HongJoonLee, ChorongJang, Ho-ShikKim, , Young-JinCho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.6 12 483-489 (7 pages)
expression and translocation of Bax to mitochondria. Our results suggest that enhanced expression and activation of p53 was responsible for the upregulation of Bax and the increased sensitivity to apoptosis, which could be reversed by p53 knockdown. To explain the observed upregulation of p53, we propose a downregulation of the ubiquitin ligase HDM2, probably translationally. These findings show the importance of appropriate RCAN1.4 expression in the modulation of cell survival and reveal a link... -
Overexpression of Ref-1 Inhibits Lead-induced Endothelial Cell Death via the Upregulation of Catalase
KwonHoLee, SangKiLee, HyoShinKim, EunJungCho, HeeKyoungJoo, EunJiLee, JiYoungLee, MyoungSooPark, SeokJongChang, Chung-HyunCho, JinBongPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.6 4 431-436 (6 pages)
significantly inhibited Pb-induced cell death in the endothelial cells. Also the overexpression of Ref-1 significantly suppressed Pb-induced superoxide and hydrogen peroxide elevation in the endothelial cells. Pb exposure induced the downregulation of catalase, it was inhibited by the Ref-1 overexpression in the endothelial cells. Taken together, our data suggests that the overexpression of Ref-1 inhibited Pb-induced cell death via the upregulation of catalase in the cultured endothelial cells. -
Upregulation of Renin-angiotensin, Endothelin and C-type Natriuretic Peptide in Rat Glomerulus with Bilateral Ureteral Obstruction
EunHuiBae, SooWanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.6 8 343-348 (6 pages)
ET-1 were increased, while that of angiotensin converting enzyme 2 was not changed. The expressions of CYP11B2 and angiotensin II receptors were not changed. C-type natriuretic peptide (CNP) expression was increased, while its receptors (natriuretic peptide receptor-B) were not changed. We suggest that the upregulation of local RAS and ET play a role in the progressive glomerular injury, and that the enhanced CNP activity also plays a compensatory role in obstructive uropathy in the glomerulus. -
Involvement of ERK1/2 and JNK Pathways in 17β-estradiol Induced Kir6.2 and SK2 Upregulation in Rat Osteoblast-like Cells
Jung-WookKim, Eun-KyoungYang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.4 6 199-206 (8 pages)
The functional expression of potassium (K) channels has electrophysiologically been studied in bone cells from several species, however, their identity and regulation of gene expressions in bone cells are not well known. In the present study, to investigate how K channel expressions are regulated by estrogen, we measured changes of transcript levels of various Ca2-activated (KCa) and ATP-sensitive K channels in rat osteoblastic ROS 17/2.8 cells after treatment with... -
Upregulation of Heat Shock Proteins in the Kidney in Hypertension
GeonLee, YoonWhaOh, JongUnLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.3 5 147-152 (6 pages)
The present study was undertaken to determine the regulation of heat shock proteins (HSP) in the kidney in hypertension. Two-kidney, one clip (2K1C) or deoxycorticosterone acetate (DOCA)-salt hypertension was induced in male Sprague-Dawley rats. At weeks 1 and 4 after inducing the hypertension, the expression of HSP70, HSP32 and HSP25 was determined in the kidney by Western blot analysis. In 2K1C hypertension, the expression of HSP70, HSP32 and HSP25 was increased in the clipped kidney at both... -
Upregulation of Renal Renin-Angiotensin System in Rats with Adriamycin-Induced Nephrosis
SooWanKim, JongUnLee, Sang-WoongHan, JunHoRyu, YoonWhaOh, NamHoKim, KiChulChoi, Ho-JungKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.2 10 127-130 (4 pages)
The present study was aimed to investigate whether the adriamycin-induced nephrosis is associated with an altered regulation of local renin-angiotensin system (RAS) in the kidney. Rats were subjected to a single injection of adriamycin (2 mg/kg body weight, IV) and kept for 6 weeks to allow the development of nephrosis. They were then divided into two groups, and supplied with and without cilazapril, an angiotensin converting enzyme (ACE) inhibitor, in drinking water (100 mg/l) for additional 6... -
Hypoosmotic shock adaptation by prolactin involves upregulation of arginine vasotocin and osmotic stress transcription factor 1 mRNA in the cinnamon clownfish Amphiprion melanopus
Park. Mi Seon, Kim. Na Na, Shin. Hyun Suk, Min. Byung Hwa, Kil. Gyung-Suk, Cho. Sung Hwoan, Choi. Cheol Young 한국통합생물학회 Animal cells and systems 9 Pages
한국통합생물학회 Animal cells and systems 2012, Vol.16 No.5 391-399 (9 pages)
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Transcriptional Upregulation of Plasminogen Activator Inhibitor-1 in Rat Primary Astrocytes by a Proteasomal Inhibitor MG132
Cho. Kyu Suk, Kwon. Kyoung Ja, Jeon. Se Jin, Joo. So Hyun, Kim. Ki Chan, Cheong. Jae Hoon, Bahn. Geon Ho, Kim. Hahn Young, Han. Seol Heu 한국응용약물학회 Biomolecules & therapeutics 7 Pages
한국응용약물학회 Biomolecules & therapeutics 2013, Vol.21 No.2 107-113 (7 pages)
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Anti-Proliferative Activity of OD78 Is Mediated through Cell Cycle Progression by Upregulation p27kip1 in Rat Aortic Vascular Smooth Muscle Cells
Tudev. Munkhtsetseg, Lim. Yong, Park. Eun-Seok, Kim. Won-Sik, Lim. Il-Ho, Kwak. Jae-Hwan, Jung. Jae-Kyung, Hong. Jin-Tae, Yoo. Hwan-Soo, 한국응용약물학회 Biomolecules & therapeutics 8 Pages
한국응용약물학회 Biomolecules & therapeutics 2011, Vol.19 No.2 187-194 (8 pages)
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Anti-inflammatory effect of methanol extract from Erigeron Canadensis L. may be involved with upregulation of heme oxygenase-1 expression and suppression of $NF{kappa}B$ and MAPKs activation in macrophages
Sung. Jeehye, Sung. Misun, Kim. Younghwa, Ham. Hyeonmi, Jeong. Heon-Sang, Lee. Junsoo 한국영양학회 Nutrition research and practice 8 Pages
한국영양학회 Nutrition research and practice 2014, Vol.8 No.4 352-359 (8 pages)
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Upregulation of Bone-like Extracellular Matrix Expression in Human Dental Pulp Stem Cells by Mechanical Strain
Han. Mi-Jung, Seo. Young-Kwon, Yoon. Hee-Hoon, Song. Kye-Yong, Park. Jung-Keug 한국생물공학회 Biotechnology and bioprocess engineering 8 Pages
한국생물공학회 Biotechnology and bioprocess engineering 2010, Vol.15 No.4 572-579 (8 pages)
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Inhibition of SIRT1 Sensitizes TRAIL-Resistant MCF-7 Cells by Upregulation of DR5 and Inhibition of c-FLIP
이수훈, 김학봉, 김미주, 이재원, 배재호, 김동완, 강치덕, 김선희, Lee. Su-Hoon, Kim. Hak-Bng, Kim. Mi-Ju, Lee. Jae-Won, Bae. Jae-Ho, Kim. Dong-Wan, Kang. Chi-Dug, Kim. S 한국생명과학회 생명과학회지 9 Pages
한국생명과학회 생명과학회지 2012, Vol.22 No.10 1277-1285 (9 pages)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)은 암세포 선택적으로 작용하므로서 유용한 항암제로 주목 받고 있다. 그러나, TRAIL 에 내성을 나타내는 암세포도 많이 존재한다. 그러므로 TRAIL 내성을 극복할 수 있는 방법을 고안하는 연구는 암 치료 요법에 매우 중요하다. 본 연구에서는 SIRT1 siRNA 또는 SIRT1 inhibitor인 amurensin G를 사람 유방암세포에 처리하면 DR5및 c-Myc의 발현 증강과 c-$FLIP_{L/S}$ 및 Mcl-1 발현 억제를 유도하므로서, TRAIL 에 내성을 나타내는 사람유방암세포 MCF-7 세포의 TRAIL... -
Upregulation of miR-23b Enhances the Autologous Therapeutic Potential for Degenerative Arthritis by Targeting PRKACB in Synovial Fluid-Derived Mesenchymal Stem Cells from Patients
Ham. Onju, Lee. Chang Youn, Song. Byeong-Wook, Lee. Se-Yeon, Kim. Ran, Park. Jun-Hee, Lee. Jiyun, Seo. Hyang-Hee, Lee. Chae Yoon, Chung. 한국분자세포생물학회 Molecules and cells 8 Pages
한국분자세포생물학회 Molecules and cells 2014, Vol.37 No.6 449-456 (8 pages)
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Dietary Hempseed Meal Intake Increases Body Growth and Shortens the Larval Stage via the Upregulation of Cell Growth and Sterol Levels in Drosophila melanogaster
Lee. Min-Jung, Park. Min-Soo, Hwang. Soo-Jin, Hong. Yoon-Ki, Choi. Ga-Hee, Suh. Yoon-Seak, Han. Seung-Yeop, Kim. Da-Rae, Jeun. Jung-Ae, O 한국분자세포생물학회 Molecules and cells 8 Pages
한국분자세포생물학회 Molecules and cells 2010, Vol.30 No.1 29-36 (8 pages)
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Upregulation of Cytosolic $NADP^+$-Dependent Isocitrate Dehydrogenase by Hyperglycemia Protects Renal Cells Against Oxidative Stress
Lee. Soh-Hyun, Ha. Sun-Ok, Koh. Ho-Jin, Kim. Kil-Soo, Jeon. Seon-Min, Choi. Myung-Sook, Kwon. Oh-Shin, Huh. Tae-Lin 한국분자세포생물학회 Molecules and cells 6 Pages
한국분자세포생물학회 Molecules and cells 2010, Vol.29 No.2 203-208 (6 pages)
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The Protective Effects of Curcuma longa Linn. Extract on Carbon Tetrachloride-Induced Hepatotoxicity in Rats via Upregulation of Nrf2
Lee. Hyeong-Seon, Li. Li, Kim. Hyun-Kyung, Bilehal. Dinesh, Li. Wei, Lee. Dong-Seok, Kim. Yong-Ho 한국미생물생명공학회 Journal of microbiology and biotechnology 8 Pages
한국미생물생명공학회 Journal of microbiology and biotechnology 2010, Vol.20 No.9 1331-1338 (8 pages)
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Upregulation of Lipopolysaccharide-Induced Interleukin-10 by Prostaglandin $A_1$ in Mouse Peritoneal Macrophages
Kim. Hyo-Young, Kim. Jae-Ryong, Kim. Hee-Sun 한국미생물생명공학회 Journal of microbiology and biotechnology 9 Pages
한국미생물생명공학회 Journal of microbiology and biotechnology 2008, Vol.18 No.6 1170-1178 (9 pages)
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Protein Tyrosine Kinases, $p56^{lck};and;p59^{fyn}$, MAP Kinase JNK1 Provide an Early Signal Required for Upregulation of Fas Ligand Expression in Aburatubolactam C-Induced Apoptosis of Human Jurkat T Cells
BAE. MYUNG AE, JUN. DO YOUN, KIM. KYUNG MIN, KIM. SANG KOOK, CHUN. JANG SOO, TAUB. DENNIS, PARK. WAN, MOON. BYUNG-JO, KIM. YOUNG HO 한국미생물생명공학회 Journal of microbiology and biotechnology 11 Pages
한국미생물생명공학회 Journal of microbiology and biotechnology 2005, Vol.15 No.4 756-766 (11 pages)
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Cell Growth of BG-1 Ovarian Cancer Cells was Promoted by 4-Tert-octylphenol and 4-Nonylphenol via Downregulation of TGF-β Receptor 2 and Upregulation of c-myc
Park. Min-Ah, Hwang. Kyung-A, Lee. Hye-Rim, Yi. Bo-Rim, Choi. Kyung-Chul 한국독성학회 Toxicological research 7 Pages
한국독성학회 Toxicological research 2011, Vol.27 No.4 253-259 (7 pages)
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Upregulation of IP-10(CXCL10) mRNA Expression by Interleukin-18
김희선, Kim. Hyo-Young, Kim. Hee-Sun 영남의대학술지편집위원회 영남의대 학술지 12 Pages
영남의대학술지편집위원회 영남의대 학술지 2007, Vol.24 No.1 67-78 (12 pages)
Interferon-${gamma}$ (IFN-${gamma}$)의 주된 생산세포는 림프구이며 주로 Interleukin-18(IL-18)에 의해 생산이 된다. IP-10은 IFN-${gamma}$에 의해 유도, 생산되는 대표적인 케모카인이다. 따라서 본 연구는 마우스 복강내 대식세포에서의 IL-18에 의한 IP-10의 생산 여부를 관찰하고자하였다. IL-18은 마우스 복강내 대식세포에서 IP-10의 발현을 직접적으로 유도 하지는 않았다. 그러나 대식세포에 지다당질을 처리하기 전 IL-18을 전 처리 시킨 결과 지다당질에 의해 유도된 IP-10의 발현이 항진되어 나타남을 확인하였다. 이러한... -
Upregulation of HIF-1α by Hypoxia Protect Neuroblastoma Cells from Apoptosis by Promoting Survivin Expression
Zhang. Bo, Yin. Cui-Ping, Zhao. Qian, Yue. Shou-Wei 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 7 Pages
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 2014, Vol.15 No.19 8251-8257 (7 pages)
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Upregulation of STK15 in Esophageal Squamous Cell Carcinomas in a Mongolian Population
Chen. Guang-Lie, Hou. Gai-Ling, Sun. Fei, Jiang. Hong-Li, Xue. Jin-Feng, Li. Xiu-Shen, Xu. En-Hui, Gao. Wei-Shi, Cao. Jian-Ping 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 4 Pages
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 2014, Vol.15 No.15 6021-6024 (4 pages)
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5-Fluorouracil and Interleukin-2 Immunochemotherapy Enhances Immunogenicity of Non-Small Cell Lung Cancer A549 Cells through Upregulation of NKG2D Ligands
Zhao. Lei, Wang. Wen-Jia, Zhang. Jin-Nan, Zhang. Xing-Yi 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 6 Pages
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 2014, Vol.15 No.9 4039-4044 (6 pages)
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