자료유형
발행기관
- 대한신경정신의학회(64)
- 대한생리학회-대한약리학회(35)
- 대한약리학회(14)
- 대한수의학회(5)
- 대한약학회(4)
- 대한화학회(4)
- 한국미생물생명공학회(3)
- 한국생약학회(3)
- 대한생리학회(2)
- 대한화장품학회(2)
- 한국생명과학회(2)
- 한국생물공학회(2)
- 한국식물병리학회(2)
- 한국음악치료학회(2)
- 경락경혈학회(1)
- 대한생물정신의학회(1)
- 대한신경계작업치료학회(1)
- 대한임상약리학회(1)
- 대한침구학회(1)
- 대한한방안이비인후피부과학회(1)
- 생화학분자생물학회(1)
- 한국곤충학회(1)
- 한국버섯학회(1)
- 한국수산과학회(1)
- 한국식품과학회(1)
- 한국식품저장유통학회(1)
- 한국원예학회(1)
- 한국응용약물학회(1)
- 한국자원식물학회(1)
- 한국종교교육학회(1)
- 한국탄소학회(1)
간행물
- 신경정신의학(64)
- THE KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY(35)
- 대한약리학잡지(14)
- ARCHIVES OF PHARMACAL RESEARCH : A PUBLICATION OF THE PHARMACEUTICAL SOCIETY OF KOREA(3)
- KOREAN JOURNAL OF VETERINARY RESEARCH(구 대한수의학회지)(3)
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY(2)
- JOURNAL OF VETERINARY SCIENCE(2)
- NATURAL PRODUCT SCIENCES(2)
- THE PLANT PATHOLOGY JOURNAL (2)
- 대한생리학회지(2)
- 대한화장품학회지(2)
- 대한화학회지(2)
- 생명과학회지(2)
- 한국생물공학회지(2)
- 한국음악치료학회지(2)
- CARBON LETTERS(1)
- JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY(1)
- KOREAN JOURNAL OF ENTOMOLOGY(1)
- THE JOURNAL OF APPLIED PHARMACOLOGY : THE OFFICIAL JOURNAL OF THE KOREAN SOCIETY OF APPLIED PHARMACO(1)
- 경락경혈학회지= KOREAN JOURNAL OF ACUPUNCTURE(1)
- 대한침구학회지= THE JOURNAL OF KOREAN ACUPUNCTURE & MOXIBUSTION SOCIETY(1)
- 산업미생물학회지(1)
- 생물정신의학(1)
- 생약학회지(1)
- 약학회지(1)
- 원예과학기술지(1)
- 임상약리학회지= THE JOURNAL OF KOREAN SOCIETY FOR CLINICAL PHARMACOLOGY AND THERAPEUTICS(1)
- 재활치료과학(1)
- 종교교육학연구(1)
- 한국미생물-생명공학회지(1)
- 한국버섯학회지(1)
- 한국생화학회지(1)
- 한국식품과학회지(1)
- 한국식품저장유통학회지(1)
- 한국양식학회지(1)
- 한국자원식물학회지(1)
- 한방안이비인후피부과학회지(1)
전체 선택해제
총 161건 검색
본문검색 결과만 보기
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Antioxidant Effects of Serotonin and L-DOPA on Oxidative Damages of Brain Synaptosomes
SangSooHam, DongHyunKim, SukHaLee, YunSangKim, ChungSooLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.2 4 147-155 (9 pages)
EDTA, H2O2 and ascorbate or xanthine and xanthine oxidase was significantly decreased by serotonin and L-DOPA (1 mM). Equal concentrations of serotonin and L-DOPA restored synaptosomal Ca2 uptake decreased by Fe2 and ascorbate, which is responsible for SOD and catalase. Protective effects of serotonin and L-DOPA on brain synaptosomes may be attributed to their removing action on reactive oxidants, hydroxyl radicals and probably iron-oxygen complex, without chelating action on iron. -
분광광도계를 이용한 L-tyrosine과 L-DOPA 혼합물의 분석방법
김지현, 유영제 한국생물공학회 한국생물공학회지 4 Pages
한국생물공학회 한국생물공학회지 1990, Vol.5 No.2 191-194 (4 pages)
Tytosine은 방향족 아미노산이고, L-DOPA는 orth위치에 수산화기를 하나 더 가지는 tyrosine유도체이다. L-DOPA는 효소에 의하여 tyrosine으로부터 전환되어 생성할 수 있는데 반응액에서 두 물질을 분리, 분석하는 것은 상당히 어렵다. 본 논문에서는 두 아미노산 혼합물을 UV/VIS spetrophotermeter를 이용하여 동정함으로써 두 물질이 구분되는 두 파장을 결정하였고 두 파장에서 혼합물의 흡광도를 측정함으로써 농도를 정량하는 분석 system을 확립하였다. 이 방법은 사료에 아무런 전처리가 필요없으므로 손쉽고 간단하게 분석에... -
Production of L-DOPA by Thermostable Tyrosine Phenol-lyase of a Thermophilic Symbiobacterium Species Overexpressed in Recombinant Escherichia coli
Lee. Seung-Goo, Ro. Hyeon-Su, Hong. Seung-Pyo, Kim. Eun-Hwa, Sung. Moon-Hee 한국미생물생명공학회 Journal of microbiology and biotechnology 5 Pages
한국미생물생명공학회 Journal of microbiology and biotechnology 1996, Vol.6 No.2 98-102 (5 pages)
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Fluphenazine , Lithium 및 L- dopa 가 가토 혈중 주정농도에 미치는 영향에 관한 실험적 연구
대한신경정신의학회 신경정신의학 1974, 제 13권 제 4호 12 466-474 (9 pages)
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보조 형광증가제를 이용한 L-Dopa의 형광분광법적 정량
이상학, 안정미, Lee. Sang Hak, Ahn. Jung Mi 대한화학회 대한화학회지 6 Pages
대한화학회 대한화학회지 2000, Vol.44 No.6 541-546 (6 pages)
및 방출파장의 방출세기에 대한 영향을 조사하였다. 보조 형광증가제로서 Lu(III) 이온을 첨가하였을때 Tb(III) 이온의 방출세기가 현저히 증가함을 관찰하였고, L-dopa의 검출한계를 낮출 수 있었다. 보조 형광증가제를 첨가하지 않았을 경우에 L-dopa 검정곡선의 직선감응범위는 들뜸파장, pH 및 Tb(Ⅲ) 이온의 농도가 각각 300 nm, 8.0 및 $1.0{ imes}10^{-4}$ M였을때, $5.0{ imes}10^{-7}$ M~$1.0{ imes}10^{-4}$ M였다. 이 조건에서의 검출한계는 $4.0{ imes}10^{-8}$ M였다. 보조 형광증가제를 첨가하였을 경우에는 들뜸파장, pH,... -
Chelidonine이 PC12 세포내의 L-DOPA-유도 세포독성에 미치는 영향
김유미, 이재준, 김춘매, 양유정, 강민희, 이명구, Kim. Yu-Mi, Lee. Jae-Joon, Jin. Chun-Mei, Yang. Yoo-Jung, Kang. Min-Hee, Lee. Myung-Koo 한국생약학회 생약학회지 4 Pages
한국생약학회 생약학회지 2003, Vol.34 No.3 242-245 (4 pages)
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Inhibition of L-DOPA-Induced Increase in Dopamine Content by $(1R,9S)-{eta}-Hydrastine$ Hydrochloride in PC12 cells
Yin. Shou-Yu, Lee. Jae-Joon, Kim. Yu-Mi, Jin. Chun-Mei, Yang. Yoo-Jung, Kang. Min-Hee, Lee. Myung-Koo 한국생약학회 Natural product sciences 5 Pages
한국생약학회 Natural product sciences 2004, Vol.10 No.3 119-123 (5 pages)
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니켈(II)-거대고리 착물로 변성된 유리질 탄소 전극을 이용한 L-Dopa의 전기화학적 정량
이선용, 조형화, 김호식, 배준웅, Yi. Seon-Yong, Cho. Hyung-Hwa, Kim. Ho-Sik, Bae. Zun-Ung 대한화학회 대한화학회지 9 Pages
대한화학회 대한화학회지 2005, Vol.49 No.1 47-55 (9 pages)
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Liriodenine Inhibits Dopamine Biosynthesis and L-DOPA-Induced Dopamine Content in PC12 Cells
Jin. Chun-Mei, Lee. Jae-Joon, Yang. Yoo-Jung, Kim. Yu-Mi, Kim. Young-Kyoon, Ryu. Shi-Yong, Lee. Myung-Koo 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 7 Pages
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 2007, Vol.30 No.8 984-990 (7 pages)
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Effects of Tributyltin Acetate on Dopamine Biosynthesis and L-DOPA-Induced Cytotoxicity in PC12 Cells
Kim. Yu-Mi, Lee. Jae-Joon, Park. Seung-Kook, Lim. Sung-Cil, Hwang. Bang-Yeon, Lee. Chong-Kil, Lee. Myung-Koo 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 8 Pages
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 2007, Vol.30 No.7 858-865 (8 pages)
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Effects of Tributyltin Chloride on L-DOPA-Induced Cytotoxicity in PC12 Cells
Lee. Jae-Joon, Kim. Yu-Mi, Park. Seung-Kook, Lee. Myung-Koo 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 6 Pages
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 2006, Vol.29 No.8 645-650 (6 pages)
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재조합 대장균에서 과발현된 Citorbacter Freundii KCTC2006 유래의 ${eta}$-Tyrosinase를 이용한 3,4-Dihydroxyphenyl-L-alannine의 생산
이승구, 노현수, 홍승표, 이규종, 왕지원, 태동년, 엄기남, 방상구, 김영준, 성문희, Lee. Seung-Goo, Ro. Hyeon-Su, Hong. Seung-Pyo, Lee. Kyu-Jong, Wang. Ji-Won, Tae. Dong-Nyeon, U 한국미생물생명공학회 산업미생물학회지 6 Pages
한국미생물생명공학회 산업미생물학회지 1996, Vol.24 No.1 44-49 (6 pages)
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Ethyl linoleate inhibits α-MSH-induced melanogenesis through Akt/GSK3β/β-catenin signal pathway
Gyeong-AKoSomiKimCho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.1 6 53-61 (9 pages)
Ethyl linoleate is an unsaturated fatty acid used in many cosmetics for its various attributes, such as antibacterial and anti-inflammatory properties and clinically proven to be an effective anti-acne agent. In this study, we investigated the effect of ethyl linoleate on the melanogenesis and the mechanism underlying its action on melanogenesis in B16F10 murine melanoma cells. Our results revealed that ethyl linoleate significantly inhibited melanin content and intracellular tyrosinase activity... -
ERK Activation by Fucoidan Leads to Inhibition of Melanogenesis in Mel-Ab Cells
YuSeokSong, MarieCarmelBalcos, Hye-YoungYun, KwangJinBaek, NyounSooKwon, Myo-KyoungKim, Dong-SeokKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.1 5 29-34 (6 pages)
Fucoidan, a fucose-rich sulfated polysaccharide derived from brown seaweed in the class Phaeo-phyceae, has been widely studied for its possible health benefits. However, the potential of fucoidan as a possible treatment for hyperpigmentation is not fully understood. This study investigated the effects of fucoidan on melanogenesis and related signaling pathways using Mel-Ab cells. Fucoidan significantly decreased melanin content. While fucoidan treatment decreased tyrosinase activity, it did not... -
Differential Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on Motor Behavior and Dopamine Levels at Brain Regions in Three Different Mouse Strains
Keun-SungLee, Jin-KooLee, Hyung-GunKim, HakRimKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.1 13 89-97 (9 pages)
Developing an animal model for a specific disease is very important in the understanding of the underlying mechanism of the disease and allows testing of newly developed new drugs before human application. However, which of the plethora of experimental animal species to use in model development can be perplexing. Administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a very well known method to induce the symptoms of Parkinson's disease in mice. But, there is very limited... -
Lithium-induced Increase of Synaptosomal Uptake of Norepinephrine in Rat Brain
Young-WukCho, Seung-HoHan, Chang-JuKim, Byung-IlMin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.2 2 127-133 (7 pages)
Lithium remains the most widely used therapeutic agent for bipolar affective disorder, particularly mania. Although many investigators have studied the effects of lithium on abnormalities in monoamine neurotransmitter as a pathophysiological basis of affective disorder, the action mechanism of lithium ion remains still unknown. To explore the action mechanism of lithium in the brain, we examined the effects of lithium on the extrasynaptosomal concentrations of catecholamines and their... -
Effects of Treadmill Exercise on the Recovery of Dopaminergic Neuron Loss and Muscle Atrophy in the 6-OHDA Lesioned Parkinson's Disease Rat Model
Myoung-AeChoe, Byung-SooKoo, GyeongJuAn, SongheeJeon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.5 3 305-312 (8 pages)
This study was to determine the effect of exercise on the recovery of dopaminergic neuron loss and muscle atrophy in 6-OHDA-induced hemi Parkinson's disease model. Exercise was loaded twice per day for 30 minutes each time, at 5 days after 6-OHDA lesioning and continued for 16 days using a treadmill. Exercise significantly increased the number of tyrosine hydroxylase positive neuron in the lesioned substantia nigra and the expression level of tyrosine hydroxylase in the striatum compared with... -
우엉(Arctium lappa L.) 뿌리 Polyphenol Oxidase의 부분정제 및 특성
임정호, 정문철, 문광덕, Lim. Jeong-Ho, Jeong. Moon-Cheol, Moon. Kwang-Deog 한국식품저장유통학회 한국식품저장유통학회지 7 Pages
한국식품저장유통학회 한국식품저장유통학회지 2005, Vol.12 No.5 489-495 (7 pages)
온도는 각각 7.0과 35$circC$이었으며, pH 2와 6 사이의 산성조건과, pH 8과 10 사이의 알카리 조건에서는 활성이 감소되거나 상실되었다. 온도에 대한 영향을 살펴본 결과, 40$circC$까지 비교적 안정한 활성을 나타내고 있었으나, 50$circC$에서 30분간 정치 시 효소활성을 50%이상 감소하는 것으로 나타내었다. 이 효소는 catechol과 L-DOPA에 대하여 높은 효소활성을 나타내었으며, chlorogenic acid과 catechol에 대한 Km 값은 각각 16.18 mM과 23.11 mM이었다. Ascorbic acid와 L-cysteine은 우엉 뿌리 polyphenol oxidase의... -
Anti-melanogenic effects of black, green, and white tea extracts on immortalized melanocytes
Young Chul Kim, So Young Choi, Eun Ye Park 대한수의학회 Journal of Veterinary Science 9 Pages
대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 2호 1 135-143 (9 pages)
Tea contains polyphenols and is one of the most popular beverages consumed worldwide. Because most tyrosinase inhibitors that regulate melanogenesis are phenol/catechol derivatives, this study investigated the inhibitory effects of Camellia sinensis water extracts (CSWEs), including black tea, green tea, and white tea extracts, on melanogenesis using immortalized melanocytes. CSWEs inhibited melanin accumulation and melanin synthesis along with tyrosinase activity in a concentration-dependent... -
Enhanced tyrosine hydroxylase expression in PC12 cells co-cultured with feline mesenchymal stem cells
Guang-Zhen Jin, Xi-Jun Yin, Xian-Feng Yu, Su-Jin Cho, Hyo-Sang Lee, Hyo-Jong Lee, Il-Keun Kong* 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2007, 제 8권 제 4호 10 377-382 (6 pages)
Mesenchymal stem cells (MSCs) secrete a variety of neuroregulatory molecules, such as nerve growth factor, brain-derived neurotrophic factor, and glial cell-derived neurotrophic factor, which upregulate tyrosine hydroxylase (TH) gene expression in PC12 cells. Enhancing TH gene expression is a critical step for treatment of Parkinson's disease (PD). The objective of this study was to assess the effects of co-culturing PC12 cells with MSCs from feline bone marrow on TH protein expression. We... -
The effects of green tea (Camellia sinensis) flower extract on melanin synthesis in B16-F10 melanoma cells
Chanuri-Yashara Dissanayake, Hae-Hee Moon, Kyeong-Mi Yang, Younjae Lee, Chang-Hoon Han 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 8 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2018, 제 58권 제 2호 1 65-72 (8 pages)
The present study observed the effects of a green tea (Camellia sinensis) flower extract (GTFE) on melanin synthesis in B16-F10 melanoma cells. GTFE exhibited antioxidant activity on 2,2-diphenyl-1-picrylhydrazyl and inhibited mushroom tyrosinase activity in a dose-dependent manner. Furthermore, GTFE significantly diminished α-melanocyte stimulating hormone (α-MSH) stimulated cellular melanin content and tyrosinase activity throughout the concentration range evaluated. Based on RNA sequencing... -
Artemisia capillaris Thunb. inhibits melanin synthesis activity via ERK-dependent MITF pathway in B16/F10 melanoma cells
Evelyn Saba , Mi Ju Oh , Yuan Yee Lee , Dongmi Kwak , Suk Kim , Man Hee Rhee 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 7 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2018, 제 58권 제 1호 1 1-7 (7 pages)
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Dipeptides Inhibit Melanin Synthesis in Mel-Ab Cells through Down-Regulation of Tyrosinase
Hyun-eLee, Eun-HyunKim, Hye-RyungChoi, UyDongSohn, Hye-YoungYun, KwangJinBaek, NyounSooKwon, Kyoung-ChanPark, Dong-SeokKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.4 9 287-291 (5 pages)
This study investigated the effects of proline-serine (PS) and valine-serine (VS) dipeptides on melanogenesis in Mel-Ab cells. Proline-serine and VS significantly inhibited melanin synthesis in a concentration-dependent manner, though neither dipeptide directly inhibited tyrosinase activity in a cell-free system. Both PS and VS down-regulated the expression of microphthalmia-associated transcription factor (MITF) and tyrosinase. In a follow-up study also described here, the effects of these... -
抗精神病藥物이 血清 Dopamine-b-Hydroxylase 活性度에 미치는 影響
薛弦旭, 禹鐘仁, 李定均 대한신경정신의학회 신경정신의학 10 Pages
대한신경정신의학회 신경정신의학 1983, 제 22권 제 2호 2 170-179 (10 pages)
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d-Amphetamine이 백서뇌의 5-HT, 5-HIAA, MAO 및 행동에 미치는 영향에 관한 연구
서유헌(Yoo Hun Suh), 우종인(Jong In Woo)박찬웅(Chan Woong Park) 대한약리학회 대한약리학잡지 16 Pages
대한약리학회 대한약리학잡지 1981, 제 17권 제 2호 6 47-62 (16 pages)
d-amphetamine이 사람에서 paranoid schizophrenia와 아주 유사한 model psychosis를 일으키며 또한 사람과 실험동물에서 실제 정신분열증에서 뚜렷이 관찰되는 behavioral perservation을 일으킬 수 있음이 관찰되었다. 이에 많은 학자들은 이러한 양상의 행동변화가 정신분열증의 원인 추구에 중요한 의미를 주는 뇌변화를 반영할지도 모른다는 생각에 많은 연구를 거듭하여 왔다. 지금까지는 주로 catecholamine기전에 대하여 집중적 연구가 수행되어져 왔으나 최근에는 d-amphetamine의 약리기전의 일부는 5-HT기전이 차지하고... -
Catecholamines 에 관(關)하여 -제일편(第一編) Catecholamines의 생성(生成), 저장(貯藏), 유리(遊離) 및 대사(代謝)-
이자주(Lee, W.C.), 대한약리학회 대한약리학잡지 20 Pages
대한약리학회 대한약리학잡지 1971, 제 7권 제 1호 1 1-20 (20 pages)
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Effects of Yukmigeehwang-hwan Pharmacopuncture Extracts on the Collagenase Activity and Procollagen Synthesis in HS68 Human Fibroblasts and Tyrosinase Activity
이세나, 김명규, 김명희, 김형준, 조학준, 김이화, 임강현, Lee. Se-Na, Kim. Myung-Gyou, Kim. Myoung-Hee, Kim. Hyung-Jun, Jo. Hak-Jun, Kim. Ee-Hwa, Leem. Kang-Hyun 경락경혈학회 경락경혈학회지= Korean journal of acupuncture 8 Pages
경락경혈학회 경락경혈학회지= Korean journal of acupuncture 2011, Vol.28 No.1 39-46 (8 pages)
방법 : HS68 사람 정상 섬유아세포에 UVB 조사 후 육미지황환(六味地黃丸) 약침액(藥鍼液)가 type I procollagen 생성과 콜라게나제 효소활성에 미치는 효능과 티로시나제 효소활성에 미치는 효능을 평가하였다. 결과 : 육미지황환(六味地黃丸) 약침액(藥鍼液)은 UVB 조사된 세포의 콜라게나제 효소활성을 통계적으로 유의하게 억제하였고, 티로시나제 활성과 L-DOPA oxidation 활성 또한 통계적으로 유의하게 억제하였다. 그러나 티로시나제와 L-DOPA oxidation 억제활성의 정도는 미약하였다. 결론 : 육미지황환(六味地黃丸) 약침액(藥鍼液)의... -
KHG26792 Inhibits Melanin Synthesis in Mel-Ab Cells and a Skin Equivalent Model
HailanLi, JiKim, Hoh-GyuHahn, JunYun, Hyo-SoonJeong, Hye-YoungYun, KwangJinBaek, NyounSooKwon, YoungSilMin, Kyoung-ChanPark, Dong-SeokKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.3 8 249-254 (6 pages)
The purpose of this study is to characterize the effects of KHG26792 (3-(naphthalen-2-yl(propoxy) methyl)azetidine hydrochloride), a potential skin whitening agent, on melanin synthesis and identify the underlying mechanism of action. Our data showed that KHG26792 significantly reduced melanin synthesis in a dose-dependent manner. Additionally, KHG26792 downregulated microphthalmiaassociated transcription factor (MITF) and tyrosinase, the rate-limiting enzyme in melanogenesis, although... -
Alteration of Striatal Tetrahydrobiopterin in Iron-Induced Unilateral Model of Parkinson’s Disease
BijayAryal, Jin-KooLee, , HakRimKim, , Hyung-GunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.2 6 129-134 (6 pages)
It has been suggested that transition metal ions such as iron can produce an oxidative injuries to nigrostriatal dopaminergic neurons, like Parkinson’s disease (PD) and subsequent compensative increase of tetrahydrobiopterin (BH4) during the disease progression induces the aggravation of dopaminergic neurodegeneration in striatum. It had been established that the direct administration of BH4 into neuron would induce the neuronal toxicity in vitro. To elucidate a role of BH4 in patho-genesis in... -
Monoamine Oxidase Inhibitors Attenuate Cytotoxicity of 1-Methyl-4-phenylpyridinium by Suppressing Mitochondrial Permeability Transition
ChungSooLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.4 7 207-212 (6 pages)
Mitochondrial permeability transition has been shown to be involved in neuronal cell death. Mitochondrial monoamine oxidase (MAO)-B is considered to play a part in the progress of nigrostriatal cell death. The present study examined the effect of MAO inhibitors against the toxicity of 1-methyl-4- phenylpyridinium (MPP) in relation to the mitochondrial permeability transition. Chlorgyline (a selective inhibitor of MAO-A), deprenyl (a selective inhibitor of MAO-B) and tranylcypromine (non-... -
The Hypothalamo-Pituitary-Adrenal (HPA) Axis in Depressed Patients
Byung-Jo Kang, Uriel Halbreich 대한신경정신의학회 신경정신의학 18 Pages
대한신경정신의학회 신경정신의학 1984, 제 23권 제 4호 2 329-346 (18 pages)
우울증 :환자에서의 시상하부ᅳ뇌하수체_ 부신피질축의 이상소견들은 뇌의 창문으르 역활할지도 모르는 신 경내분비계통이 중요하다는 하나의 좋은 예이 다. 우울증환자에 있어서 중추신경에 작용하는 약물들(amphetamine, insulin, desmethylimipramin, 5-hydroxytryptophan)에 대한 cortis이의 비정상적인 반응은 그 밑바닥에 있는 신경전달물질들의 장애에 대한 단서를 제공해 줄수도 있다. 우울증에 관한 이와같은 연구들은 여 러가지 문제점 들을 내포하고 있다. 예를들면 cortisol분비에 영향을 주는 몇몇 신체적이고... -
지연성 운동장애 환자에서 뇌 척수액 丫-Aminobutyric Acid 농도에 관한 연구
권준수, 김재진, 우종인 대한신경정신의학회 신경정신의학 10 Pages
대한신경정신의학회 신경정신의학 1990, 제 29권 제 6호 5 1245-1254 (10 pages)
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Calcineurin-Responsive Transcription Factor CgCrzA Is Required for Cell Wall Integrity and Infection-Related Morphogenesis in Colletotrichum gloeosporioides
Ping Wang, Bing Li, Yu-Ting Pan, Yun-Zhao Zhang, De-Wei Li, Lin Huang 한국식물병리학회 The Plant Pathology Journal 13 Pages
한국식물병리학회 The Plant Pathology Journal 2020, 36권 5호 1 385-397 (13 pages)
The ascomycete fungus Colletotrichum gloeosporioides infects a wide range of plant hosts and causes enormous economic losses in the world. The transcription factors (TFs) play an important role in development and pathogenicity of many organisms. In this study, we found that the C2H2 TF CgCrzA is localized in both cytoplasm and nucleus under standard condition, and it translocated from cytoplasm to nucleus in a calcineurin- dependent manner. Moreover, the ΔCgCrzA was hypersensitive to cell wall... -
Anti-Oxidant Property and Inhibition of Melanin Synthesis of Eight Plant Extracts
김재영, 이진영, 이위영, 이용섭, 임융호, Kim. Jae-Young, Lee. Jin-Young, Lee. Wi-Young, Yi. Yong-Sub, Lim. Yoong-Ho 한국미생물생명공학회 한국미생물·생명공학회지 6 Pages
한국미생물생명공학회 한국미생물·생명공학회지 2010, Vol.38 No.4 414-419 (6 pages)
16.4 mg/g로 가장 높은 추출량을 나타내었다. 항산화 활성 측정에서는 Acer ginnala 에서 $IC_{50}$값으로 $21.3;{mu}g/mL$으로 가장 좋은 활성을 나타내었다. 반면에 L-DOPA를 기질로 하여 mushroom tyrosinase의 활성 억제측정에서는 Distylum racemosum 1,000 mg에서 49.1%로 다른 추출물에 비하여 상대적으로 높은 활성을 나타내었다. Tyrosinase 활성 억제력이 가장 높은 D. racemosum의 추출물을 이용하여 ethanol 분획과 ethyl acetate 분획으로 분리하여, 이중 D. racemosum의 ethanol 분획에서 항산화 활성 $IC_{50}$ 값은... -
Vitabrid-C를 함유한 피부 미백용 트윈케익 파우더 개발
이선영, 양재훈, 한양수, 이승화, 홍성호, 최진호 대한화장품학회 大韓化粧品學會誌 16 Pages
대한화장품학회 大韓化粧品學會誌 2003, Vol.29 No.1 169-184 (16 pages)
C 에 비해 우수한 안정성을 보였으며, 캡슐 내 비타민 C 가 서서히 방출되는 서방특성을 발휘하였다. 또한 Vitabrid-C는 입자의 크기가 미세하고 균일하여 트윈케익 처방에 용이하게 적용할 수 있었다. Vitabrid-C와 순수 비타민 C의 생화학적 동등성에 대한 평가는 tyrosinase 억제능(L-DOPA oxidase 억제) 및 DPPH항산화 실험을 통하여 비교하였다. 트윈 케익 처방에 적용된 Vitabrid-C 에서 비타민 C 의 피부 투과경향을 Franz diffusion cell 법을 이용하여 확인하였다 또한 Vitabrid-C가 포함된 트윈케익을 건강한 피부를 가진 25... -
한국인 Catechol-O-Methyltransferase(COMT) 표현형 활성의 인구 집단 연구
임동석, 권순억, 장인진, 전범석, 김명석, 신상구, Yim. Dong-Seok, Keon. Soon-Uk, Jang. In-Jin, Jeon. Beom-Suk, Kim. Myung-Suk, Shin. Sang-Goo 대한임상약리학회 臨床藥理學會誌= The journal of Korean Society for Clinical Pharmacology and Therapeutics 7 Pages
대한임상약리학회 臨床藥理學會誌= The journal of Korean Society for Clinical Pharmacology and Therapeutics 1997, Vol.5 No.1 35-41 (7 pages)
내인성 카테콜아민을 비롯하여 L-dopa와 methyldopa 등을 대사시키며 상염색체를 통해 유전되는 것으로 알려져 있다. 미국의 흑인과 백인에서 그 분포에 관한 보고가 있으나 한국인을 비롯한 아시아 인종에서의 분포는 알려져있지 않고 있다. 방 법 : 한국인 적혈구내 COMT 활성의 분포양상을 파악하고 이를 타 인종과 비교하기 위하여 건강한 피험자 343명($20{sim}39$세, 평균연령 23.5세, 남/여=277/66) 을 대상으로 적혈구내 COMT 활성을 $^{14}C-S-adenosyl$ methionine을 methyl donor로 이용하여 방사화학적 방법으로 측정하였다.... -
Effects of Fetal Mesencephalic Cell Grafts on the Intrastriatal 6-hydroxydoapmine Lesioned Rats
WanSeokJoo, EunjooNam, Heh-InIm, JinAhJung, EunSunLee, Yu-JinHwang, YongSikKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.5 2 245-252 (8 pages)
The effects of fetal mesencephalic cell grafts on the restoration of nigrostriatal dopaminergic function were studied in the intrastriatal 6-hydroxydopamine-lesioned rats. Four weeks after lesioning, transplantation of ventral mesencephalic cells from embryonic day 14 fetuses showed the number of tyrosine hydroxylase (TH) positive cells and fiber outgrowth in the grafted striatum, and significantly ameliorated symptomatic motor behavior of the animals, as determined by apomorphine-induced... -
Normal Anxiety, Fear and Depression-related Behaviors in Mice Lacking α-Calcitonin Gene-Related Peptide
JonghoLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.6 4 299-304 (6 pages)
Calcitonin gene-related peptide (CGRP) expressing neurons are distributed widely throughout the central and peripheral nervous systems. Due to its distribution and pharmacological studies, CGRP has been implicated to be involved in anxiety, fear and depression. In this study, αCGRP-knockout mice were used to assess the consequences of removing this neuropeptide to the mice behaviors. αCGRP-knockout mice performed equally as well as wild type mice in the light-dark transition test and in the... -
Indomethacin Induces Apoptosis in NCI-H1299 Human Lung Carcinoma Cells
BumShikKim, SoonAeKim, MiJaKim, HeeJaeLee, Seung-JoonPark, Jee-ChangJung, Chang-JuKim, Sung-VinYim, Joo-HoChung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.2 8 177-181 (5 pages)
Recently, nonsteroidal anti-inflammatory drugs (NSAIDs) have been found to be useful in the chemoprevention of colon cancer. To investigate whether indomethacin, an NSAIDs, induces apoptosis and thus assess the possibility of its application in the chemoprevention of human lung cancer, we have performed MTT assay, TUNEL assay, DAPI staining, and flow cytometric analysis using human lung carcinoma cell line NCI-H1299. Through morphological and biochemical analyses, it was demonstrated that... -
Effect of Bromocriptine on 6-Hydroxydopamine-induced Lipid Peroxidation and Cytotoxicity in vitro and in vivo
YongSikKim, SunghoMaeng, ChanWoongPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.5 4 565-572 (8 pages)
The present study was to evaluate the protective effects of bromocriptine, which is known as D2 dopamine receptor agonist and used for the treatment of patients with Parkinson's disease (PD), on 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in vitro and in vivo. Lipid peroxidation product (malondialdehyde; MDA) produced by the administration of 6-OHDA was profoundly reduced following the treatment of bromocriptine in a dose-dependent manner in rabbit brain homogenate. Quinone formation by... -
Hexanal Vapor Induced Resistance against Major Postharvest Pathogens of Banana (Musa acuminata L.)
Durgadevi Dhakshinamoorthy, Srivignesh Sundaresan, Arumukapravin Iyadurai, Kizhaeral Sevathapandian Subramanian, Gnanaguru Janaki Janavi, Gopinathan Paliyath, Jayasankar Subramanian 한국식물병리학회 The Plant Pathology Journal 15 Pages
한국식물병리학회 The Plant Pathology Journal 2020, 36권 2호 3 133-147 (15 pages)
Hexanal, a C-6 aldehyde has been implicated to have antimicrobial properties. Hence, this study was con- ducted to determine the antifungal activities of hexanal vapor against major postharvest pathogens of banana viz., Colletotrichum gloeosporioides and Lasiodiplodia theobromae. The pathogens were cultured in vitro and exposed to hexanal vapor at 600, 800, 1,000 and 1,200 ppm. Mycelial growth of both fungal pathogens were inhibited completely at 800 ppm and the incidence of anthracnose and... -
Tetramethylpyrazine reverses anxiety-like behaviors in a rat model of post-traumatic stress disorder
Bombi Lee, Insop Shim, Hyejung Lee, Dae-Hyun Hahm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 14 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.5 6 525-538 (14 pages)
Post-traumatic stress disorder (PTSD) is a trauma-induced psychiatric disorder characterized by impaired fear extermination, hyperarousal, and anxiety that may involve the release of monoamines in the fear circuit. The reported pharmacological properties of tetramethylpyrazine (TMP) include anti-cancer, anti-diabetic, anti-atherosclerotic, and neuropsychiatric activities. However, the anxiolytic-like effects of TMP and its mechanism of action in PTSD are unclear. This study measured several... -
The efficacy of combination treatment of gabapentin and electro-acupuncture on paclitaxel-induced neuropathic pain
MinJoonKim, JiHwanLee, JoUngJang, FuShiQuan, SunKwangKim, WoojinKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.6 11 657-666 (10 pages)
Paclitaxel, a chemotherapeutic drug, induces severe peripheral neuropathy. Gabapentin (GBT) is a first line agent used to treat neuropathic pain, and its effect is mediated by spinal noradrenergic and muscarinic cholinergic receptors. Electro-acupuncture (EA) is used for treating various types of pain via its action through spinal opioidergic and noradrenergic receptors. Here, we investigated whether combined treatment of these two agents could exert a synergistic effect on paclitaxel-induced... -
Expression Profile of Neuro-Endocrine-Immune Network in Rats with Vascular Endothelial Dysfunction
LujinLi, ZhenghuaJia, LingXu, YilingWu, QingshanZheng 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.2 13 177-182 (6 pages)
This study was to determine the correlation between endothelial function and neuro-endocrine- immune (NEI) network through observing the changes of NEI network under the different endothelial dysfunction models. Three endothelial dysfunction models were established in male Wistar rats after exposure to homocysteine (Hcy), high fat diet (HFD) and Hcy+HFD. The results showed that there was endothelial dysfunction in all three models with varying degrees. However, the expression of NEI network was...
