자료유형
발행기관
- 대한생리학회-대한약리학회(260)
- 대한수의학회(98)
- 대한약리학회(68)
- 대한생리학회(59)
- 한국식물병리학회(53)
- 생화학분자생물학회(15)
- 한방비만학회(15)
- 대한신경정신의학회(12)
- 한국영양학회(5)
- 한국미생물생명공학회(4)
- 한국보건기초의학회(4)
- 한국탄소학회(4)
- 한국식품과학회(3)
- 한국식품영양과학회(3)
- 대한화학회(2)
- 물리치료재활과학회(2)
- 한국미생물학회(2)
- 한국생약학회(2)
- 한국식물학회(2)
- 경희한의학연구센터(1)
- 고려인삼학회(1)
- 대한기생충학회(1)
- 대한생식의학회(1)
- 대한소아신장학회(1)
- 대한의생명과학회(1)
- 한국기초간호학회(1)
- 한국동물학회(1)
- 한국생물공학회(1)
- 한국습지학회(1)
- 한국식품저장유통학회(1)
- 한국유화학회(1)
- 한국응용생명화학회(1)
- 한국환경농학회(1)
- 한국환경독성학회(1)
- 환경독성보건학회(1)
간행물
- THE KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY(260)
- JOURNAL OF VETERINARY SCIENCE(78)
- 대한약리학잡지(68)
- 대한생리학회지(59)
- THE PLANT PATHOLOGY JOURNAL (48)
- KOREAN JOURNAL OF VETERINARY RESEARCH(구 대한수의학회지)(19)
- 대한한방비만학회지(15)
- 신경정신의학(12)
- 한국생화학회지(11)
- 식물병연구(5)
- CARBON LETTERS(4)
- JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY(4)
- 한국보건기초의학회지(4)
- 산업미생물학회지(3)
- 한국식품과학회지(3)
- 한국식품영양과학회지(3)
- 한국영양학회지(3)
- PHYSICAL THERAPY REHABILITATION SCIENCE(2)
- 대한화학회지(2)
- 생약학회지(2)
- 식물학회지(2)
- 환경독성학회지(2)
- BIOTECHNOLOGY AND BIOPROCESS ENGINEERING(1)
- JOURNAL OF KOREAN BIOLOGICAL NURSING SCIENCE(1)
- JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY(1)
- NUTRITION RESEARCH AND PRACTICE(1)
- NUTRITIONAL SCIENCES(1)
- ORIENTAL PHARMACY AND EXPERIMENTAL MEDICINE : OPEM(1)
- THE JOURNAL OF BIOMEDICAL LABORATORY SCIENCES(1)
- THE JOURNAL OF MICROBIOLOGY(1)
- THE KOREAN JOURNAL OF PARASITOLOGY(1)
- 고려인삼학회지(1)
- 대한불임학회잡지(1)
- 대한소아신장학회지(1)
- 대한수의학회 학술대회발표집(1)
- 동물학회지(1)
- 미생물학회지(1)
- 한국습지학회지(1)
- 한국식품저장유통학회지(1)
- 한국유화학회지(1)
- 한국응용생명화학회지(1)
- 한국환경농학회지(1)
전체 선택해제
총 629건 검색
본문검색 결과만 보기
-
Glucose-6-phosphate dehydrogenase를 이용한 Moina macrocopa의 중금속 독성 검정
박용석, 이상구, 이승진, 문성경, 최은주, 이기태, Park. Yong-seok, Lee. Sang-Goo, Lee. Seung-Jin, Moon. Sung-Kyung, Choi. Eun-Joo, Rhie. Ki-tae 한국환경독성학회 환경독성학회지 6 Pages
한국환경독성학회 환경독성학회지 2003, Vol.18 No.4 305-310 (6 pages)
-
당뇨유발쥐에서 닭의장풀의 혈당감소효과와 간조직내의 Glucose-6-Phosphate Dehydrogenase의 효소활성에 미치는 효과
박수영, 조경혜, Park. Soo-Young, Cho. Kyung-Hea 한국생약학회 생약학회지 11 Pages
한국생약학회 생약학회지 1994, Vol.25 No.3 238-248 (11 pages)
-
식이 n-3 지방이 흰 쥐 간장의 Glucose-6-Phosphate Dehydrogenase와 Malic Enzyme 활성에 미치는 영향
서미영, 김혜명, 나혜경, 조성희, Suh. Mi-Young, Kim. Hae-Myung, Na. Hae-Kyung, ChoLee. Sung-Hee 생화학분자생물학회 한국생화학회지 7 Pages
생화학분자생물학회 한국생화학회지 1990, Vol.23 No.3 395-401 (7 pages)
식이 n-3 지방이 간장의 glucose-6-phosphate dehydrogenase(G6PDH)와 malic enzyme(EM) 활성에 미치는 영향을 조사하기 위하여 65-75 mg의 Sprague-Dawley종의 암, 수 흰쥐에게 고등어유와 들깨유를 조제식이의 10%(w/w)로 주어 사육하고, 비교군으로 대두유와 쇠기름을 준 두 군을 사용하였다. 3주 식이 후, 암, 수 쥐를 교배시키고, 태어난 새끼 쥐들의 초기 성장기간 동안 두 효소의 활성을 측정하고, 암, 수의 차이도 조사하였다. 젖을 먹는 동안 G6PDH와 ME 활성은 모든 군에서 매우 낮았고, 젖을 떼면서 효소활성은 증가하기... -
효모 glucose-6-phosphate dehydrogenase의 $NADP^+$ 결합부위에 있는 arginine
변혜신, 김유삼, Byun. Hye-Sin, Kim. Yu-Sam 생화학분자생물학회 한국생화학회지 5 Pages
생화학분자생물학회 한국생화학회지 1989, Vol.22 No.4 425-429 (5 pages)
단백질에서 arginine에 특이적으로 반응하는 2,3-butanedione과 phenylglyoxal을 Saccharomyes cereνisiae glucose-6-phosphate dehydrogenase의 촉매반응에 관여하는 아미노산을 밝히는데 사용하였다. 2,3-Butanedione은 biphasic mode로 즉 초기에는 빠르게 그리고 나서는 느리게 이 효소를 불활성화시켰다. 이 초기단계에서의 2차 반응속도상수는 $344.8M^{-1}min^{-1}$이었고 반응차수가 0.87인 것으로 보아서 효소분자당 한 분자의 2,3-butanedione이 작용하는 것으로 판단된다. 또 효소를 $NADP^+$와 처리하였을 때 이러한... -
오리에 있는 Glucose-6-Phosphate Dehydrogenase 한 Isozyme의 In Vitro Translation 및 그 효소의 In Vivo Isotope Labeling
이상철, 김유삼, Lee. Sang-Chul, Kim. Yu-Sam 생화학분자생물학회 한국생화학회지 4 Pages
생화학분자생물학회 한국생화학회지 1985, Vol.18 No.3 332-335 (4 pages)
6.6인 glucose-6-phosphate dehydorgenase를 분리 하고 in vivo isotope labeling된 같은 효소를 분리하여 SDS polyacrylamide disc gel electrophoresis를 통하여 비교하였다. 그 결과 in vitro translation mixture로 부터 분리한 효소와 in vivo labeling된 효소는 그것이 uropygial gland의 것이거나 간의 것이거나 모두가 uropygial gland에서 직접 정제한 효소와 같은 크기임을 알 수 있었다. 이러한 사실은 uropygial gland에 존재하는 pI 6.6인 glucose-6-phosphate dehydrogenase가 갖는 효소적 특성은 소수의 아미노산의 차이에... -
Studies on E. coli K-12 Glucose-6-phosphate Dehydrogenases from Exponential and Stationary Phases (I)
조영동, 오명석, Cho. Young-Dong, O. Myung-Seok 생화학분자생물학회 한국생화학회지 7 Pages
생화학분자생물학회 한국생화학회지 1983, Vol.16 No.3 216-222 (7 pages)
coli K-12 w 1485의 exponential phase와 stationary phase에서 얻은 glucose-6-phosphate dehydrogenase의 차이점을 관찰하여 다음과 같은 결과를 얻었다. 1) Exponential phase의 E. coli K-12로 부터 추출한 효소는 stationary phase의 E. coli K-12로 부터 추출한 효소보다도 열에 대한 안정도가 높았다. 2) Exponential phase에서 얻은 효소는 stationary phase에서 얻은 효소보다 disc gel electrophoresis에서 빠른 이동도를 나타내었다. 3) Exponential phase와 stationary phase에서 얻은 각각의 효소는 5~25% sucrose gradient... -
어피니티 크로마토그라피에 의한 Glucose-6-Phosphate Dehydrogenase의 정제
최양도, 변시명, 한문희, Choi. Yang-Do, Byun. Si-Myung, Han. Moon-H. 생화학분자생물학회 한국생화학회지 14 Pages
생화학분자생물학회 한국생화학회지 1979, Vol.12 No.3 147-160 (14 pages)
6-phosphate dehydrogenase를 Cibacron Blue F3GA-Sepharose 4B 어피니티 크로마토그라피와 하이드록시 아파타이트 크로마토그라피 방법에 의해 신속하고 경제적으로 순수 분리하였다. 배양한 세포를 초음파로 파괴하여 얻은 조효소액을 Blue-Sepharose에 어피니티 크로마토그라피한 결과 단순히 KCI gradient만을 사용해서는 glucose-6-phosphate dehydrogenase와 함께 lactate dehydrogenase가 혼합된 부분 정제밖에 얻을 수가 없었다. 그러나 이 두 효소는 다음 단계인 하이드록시 아파타이트 크로마토그라피에 의해 완전히 분리되어... -
The Reactivity of Antiserum Raised against Native Glucose-6-phosphate Dehydrogenase with Denatured Glucose-6-phosphate Dehydrogenase in Competitive ELISA
Kim. Moon-Hee 생화학분자생물학회 Journal of biochemistry and molecular biology 5 Pages
생화학분자생물학회 Journal of biochemistry and molecular biology 1998, Vol.31 No.5 519-523 (5 pages)
-
Characteristics of the Inhibitory Action of Protease Inhibitors on the Glucose-6-phosphate Transporter
Choi. Joon-Sig, Shin. Jeong-Sook, Choi. Hong-Sug, Park. Jong-Sang 생화학분자생물학회 Journal of biochemistry and molecular biology 5 Pages
생화학분자생물학회 Journal of biochemistry and molecular biology 1997, Vol.30 No.2 157-161 (5 pages)
-
Characteristics of Glucose-6-phosphate Dehydrogenase from Leuconostoc mesenteroides
변시명, 최양도, 한문희, Byun. Si Myung, Choi. Yang Do, Han. Moon H. 대한화학회 대한화학회지 11 Pages
대한화학회 대한화학회지 1979, Vol.23 No.4 248-258 (11 pages)
컬럼 어피니티크로마토그래피에 의하여 GIn-cose-6-phosphate dehydrogenase를 Leuconostoc mesenteroides로부터 순수 분리한 바 있다. 이 효소를 사용하여 효소특성을 조사한 결과 분자량은 Sephadex G-200 컬럼에 의해 112,000이었으며 최적온도는 50$^{circ}$, 활성화에너 지는 8.36kcal/mole 불활성화에너지는 -58.2kcal/mole로 나타났다. $NADP^+$를 조효소로 사용하였을때 최적 pH7.8에서 K_{G6p}:76.9${mu}$M, ${alpha}K_{NADP}:;7.46{mu}M,;{alpha}KNNADP:;7.l4{mu}M$이었으며 같은 조건에서 $NAD^+$를 조효소로 사용하였을때... -
Phage Ghost로 破裂시킨 E. coli 에서 Glucose-6-phosphate Dehydrogenase의 活性度 測定
윤세중, Yun. Se-Joong 대한화학회 대한화학회지 4 Pages
대한화학회 대한화학회지 1968, Vol.12 No.4 142-145 (4 pages)
-
Alloxan으로 유발된 당뇨쥐의 간조직 Glucose-6-Phosphate Dehydrogenase 효소의 변화
박수영, 조경혜 대한의생명과학회 The Journal of biomedical laboratory sciences 7 Pages
대한의생명과학회 The Journal of biomedical laboratory sciences 1997, Vol.3 No.2 169-175 (7 pages)
혈당치의 정상수준으로 회복하는 경향을 확인하였다. 정상군과 당뇨대조군, 약물투여군으로 나눈 실험쥐를 대상으로 간조직에서의 glucose-6-phosphate dehydrogenase (G6PD) 효소의 활성도를 측정한 결과 당뇨대조군에서는 정상군의 34.2%로 G6PD 효소 활성도가 감소되었으며 식물추출액을 투여함으로써 정상치의 61%로 회복되었다. 실험쥐 간조직내에 G6PD효소활성도의 감소 또는 회복과 G6PD isozyme분자의 구조변화와의 연관성을 알아보기 위하여 native gel 전기영동을 실시하였다. 정상쥐의 간조직에서의 G6PD isozyme형태는 band... -
Purification and Properties of Glucose 6-Phosphate Dehydrogenase from Aspergillus aculeatus
Ibraheem. Omodele, Adewale. Isaac Olusanjo, Afolayan. Adeyinka 생화학분자생물학회 Journal of biochemistry and molecular biology 7 Pages
생화학분자생물학회 Journal of biochemistry and molecular biology 2005, Vol.38 No.5 584-590 (7 pages)
-
소 체외수정란의 Glucose 6-Phosphate Dehydrogenase 활성
류재웅, 박흠대, 이경광, Ryoo. Z.Y., Park. H.D., Lee. K.K. 대한생식의학회 大韓不妊學會雜誌 7 Pages
대한생식의학회 大韓不妊學會雜誌 1995, Vol.22 No.3 301-307 (7 pages)
glucose 6-phosphate dehydrogenase (G6PDH)의 활성을 효소증폭방법으로 측정하였다. Glucose 6-phosphate (G6P) 기질을 처리하지 않은 2, 4, 8세포기, 상실배 및 배반포기 수정란에서의 G6PDH 활성치는 각각 $25.5{pm}3.3$, $27.8{pm}3.4$, $40.9{pm}6.2$, $34.9{pm}3.6$ 및 $52.9{pm}2.5{ imes}10^{-8}mol/embryo/h$ 을 나타내었다. 즉, 8 세포기 이후 수정란들은 2 세포기나 4 세포기보다도 높은 효소활성치를 보여주었다 (P<0.01). 그리고 G6P 기질을 첨가한 2,4,8 세포기, 상실배기 및 배반포기 수정란의 G6PDH 활성치는 각각... -
출생전후 및 성별로 본 쥐의 간세포에서의 G-6-PD 활성
Hahn. Sahsook 한국동물학회 동물학회지 6 Pages
한국동물학회 동물학회지 1974, Vol.17 No.1 17-22 (6 pages)
Pentose phosphate shunt의 첫 작용때 나타나는 효소 glucose-6-phosphate dehydorgenase의 활성을 출생전 및 출생후 연령에 따라서 쥐(white rat)의 간세포를 암수 성별로 spectrophotometer를 써서 측정하였다. 이 활성이 16일 된 배에서 가장 높았고 (54 I.U.), 그때부터 출생후 13일 까지 조금씩 저하되지만 (17 I.U.), 다시 서서히 증가해서 19일에는 53 I.U.까지 높아졌다. 성별로 본 결과는 일반적으로 수컷보다 암컷에서 G-6-PD의 활성이 약간 높게 나타났다. -
에르릿히 복수종양의 C14-1-포도당 및 C14-6-포도당 대사에 관한 연구
권창락(Kwon, Chang-Rak) 대한생리학회 대한생리학회지 10 Pages
대한생리학회 대한생리학회지 1967, 제 1권 제 1호 3 33-42 (10 pages)
-
Comparative Proteomic Analysis for a Putative Pyridoxal Phosphate-Dependent Aminotransferase Required for Virulence in Acidovorax citrulli
Jongchan Lee, Lynn Heo, Sang-Wook Han 한국식물병리학회 The Plant Pathology Journal 8 Pages
한국식물병리학회 The Plant Pathology Journal 2021, 37권 6호 16 673-680 (8 pages)
of a putative pyridoxal phosphate-dependent aminotransferase (PpdaAc) that transfers amino groups to its substrates and uses pyridoxal phosphate as a coenzyme. It was observed that a ppdaAc knockout mutant had a significantly reduced virulence in watermelon when introduced via germinated-seed inoculation as well as leaf infiltration. Comparative proteomic analysis predicted the cellular mechanisms related to PpdaAc. Apart from causing virulence, the PpdaAc may have significant roles in energy... -
Calcium-sensing receptor-mediated L-tryptophan-induced secretion of cholecystokinin and glucose-dependent insulinotropic peptide in swine duodenum
Xiuying Zhao, Yihan Xian, Chao Wang, Liren Ding, Xianglong Meng, Weiyun Zhu, Suqin Hang 대한수의학회 Journal of Veterinary Science 9 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 2호 4 179-187 (9 pages)
This study aimed to elucidate the effect of tryptophan (Trp) on gut hormone secretion as well as the roles of the calcium-sensing receptor (CaSR) and its downstream signaling pathway in gut hormone secretion by assessing swine duodenal perfusion in vitro. Swine duodenum was perfused with Krebs-Henseleit buffer as a basal solution. Various concentrations (0, 10, and 20 mM) of Trp were applied to investigate its effect on gut hormone secretion. A CaSR antagonist was used to detect the involvement... -
Exendin-4 Improves Nonalcoholic Fatty Liver Disease by Regulating Glucose Transporter 4 Expression in ob/ob Mice
SeokKim, JaehoonJung, HwajinKim, RokWonHeo, Chin-okYi, JungEunLee, ByeongTakJeon, Won-HoKim, JongRyealHahm, GuSeobRoh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.4 8 333-339 (7 pages)
Exendin-4 (Ex-4), a glucagon-like peptide-1 receptor (GLP-1R) agonist, has been known to reverse hepatic steatosis in ob/ob mice. Although many studies have evaluated molecular targets of Ex-4, its mechanism of action on hepatic steatosis and fibrosis has not fully been determined. In the liver, glucose transporter 4 (GLUT4) is mainly expressed in hepatocytes, endothelial cells and hepatic stellate cells (HSCs). In the present study, the effects of Ex-4 on GLUT4 expression were determined in the... -
High Glucose Induces Connective Tissue Growth Factor Expression and Extracellular Matrix Accumulation in Rat Aorta Vascular Smooth Muscle Cells Via Extracellular Signal-Regulated Kinase 1/2
YuMiHa, DongHyupLee, MinaKim, YoungJinKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.4 8 307-314 (8 pages)
Connective tissue growth factor (CTGF) is a potent pro-fibrotic factor, which is implicated in fibrosis through extracellular matrix (ECM) induction in diabetic cardiovascular complications. It is an important downstream mediator in the fibrotic action of transforming growth factor Ղ (TGFՂ) and is potentially induced by hyperglycemia in human vascular smooth muscle cells (VSMCs). Therefore, the goal of this study is to identify the signaling pathways of CTGF effects on ECM... -
4-phenylbutyric Acid Regulates Collagen Synthesis and Secretion Induced by High Concentrations of Glucose in Human Gingival Fibroblasts
Geum-HwaLee, Hyo-WonOh, Hyun-DaeLim, WanLee, Han-JungChae, Hyung-RyongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.6 5 345-352 (8 pages)
High glucose leads to physio/pathological alterations in diabetes patients. We investigated collagen production in human gingival cells that were cultured in high concentrations of glucose. Collagen synthesis and secretion were increased when the cells were exposed to high concentrations of glucose. We examined endoplasmic reticulum (ER) stress response because glucose metabolism is related to ER functional status. An ER stress response including the expression of glucose regulated protein 78... -
Effects of Fetal Mesencephalic Cell Grafts on the Intrastriatal 6-hydroxydoapmine Lesioned Rats
WanSeokJoo, EunjooNam, Heh-InIm, JinAhJung, EunSunLee, Yu-JinHwang, YongSikKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.5 2 245-252 (8 pages)
The effects of fetal mesencephalic cell grafts on the restoration of nigrostriatal dopaminergic function were studied in the intrastriatal 6-hydroxydopamine-lesioned rats. Four weeks after lesioning, transplantation of ventral mesencephalic cells from embryonic day 14 fetuses showed the number of tyrosine hydroxylase (TH) positive cells and fiber outgrowth in the grafted striatum, and significantly ameliorated symptomatic motor behavior of the animals, as determined by apomorphine-induced... -
The Enhancement of Endotoxin-Induced Nitric Oxide Production by Elevation of Glucose Concentration in Macrophage
HyunGooWoo, Yi-SookJung, EunJooBaik, Chang-HyunMoon, SooHwanLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.4 10 447-454 (8 pages)
phosphate amidotransferase (GFAT) inhibitors, significantly diminished the augmentation effect of high glucose on endotoxin-induced NO production. On the other hand, negative modulation of GFAT inhibitors was not reversed by the treatment of glucosamine, suggesting the minimal involvement, if any, of glucosamine pathway in glucose-enhancing effect. In summary, these results strongly suggest that the hexosamine biosynthesis pathway and the activation of PKC via sorbitol pathway do not contribute... -
Hexachlorophene의 간흡충(肝吸䖝)의 C-14 Glucose 및 C-14 Glycine 대사(代謝)에 미치는 영향(影響)에 관(關)한 연구(硏究)
차충석(Cha, Choong-Suk), 대한약리학회 대한약리학잡지 12 Pages
대한약리학회 대한약리학잡지 1966, 제 2권 제 2호 2 23-34 (12 pages)
-
Effects of High Glucose on Na,K-ATPase and Na/glucose Cotransporter Activity in Primary Rabbit Kidney Proximal Tubule Cells
Han, Ho-Jae 대한생리학회 대한생리학회지 12 Pages
대한생리학회 대한생리학회지 1995, 제 29권 제 1호 7 69-80 (12 pages)
Renal proximal tubular hypertrophy and hyperfunction are known to be early manifestations of experimental and human diabetes. As the hypertrophy and hyperfunction have been suggested to be central components in the progression to renal failure, an understanding of their underlying causes is potentially important for the development of therapy. A primary rabbit kidney proximal tubule cell culture system was utilized to evaluate the possibility that the renal proximal tubular hypertrophy and... -
Proteomic and Phenotypic Analyses of a Putative Glycerol-3-Phosphate Dehydrogenase Required for Virulence in Acidovorax citrulli
Minyoung Kim, Jongchan Lee, Lynn Heo, Sang Jun Lee, Sang-Wook Han 한국식물병리학회 The Plant Pathology Journal 11 Pages
한국식물병리학회 The Plant Pathology Journal 2021, 37권 1호 3 36-46 (11 pages)
of a putative glycerol-3-phosphate dehydrogenase in Ac (GlpdAc) using comparative proteomic analysis and phenotypic observation. A glpdAc knockout mutant, AcΔglpdAc(EV), lost virulence against watermelon in two pathogenicity tests. The putative 3D structure and amino acid sequence of GlpdAc showed high similarity with glycerol-3-phosphate dehydrogenases from other bacteria. Comparative proteomic analysis revealed that many proteins related to various metabolic pathways, including carbohydrate... -
Effect of glucose level on chemical hypoxia- and hydrogen peroxide-induced chemokine expression in human glioblastoma cell lines
YieunJung, So-HeeAhn, SangHuiPark, Youn-HeeChoi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.5 6 509-518 (10 pages)
Glioblastoma multiforme (GBM) is the most common primary intracranial tumor in adults and has poor prognosis. The GBM-specific tumor microenvironment (TME) plays a crucial role in tumor progression, immune escape, local invasion, and metastasis of GBM. Here, we demonstrate that hypoxia, reactive oxygen species (ROS), and differential concentration of glucose influence the expression of cytokines and chemokines, such as IL-6, IL-8, and IP-10, in human glial cell lines. Treatment with cobalt... -
The production and distribution of IL-6 and TNF-α in subcutaneous adipose tissue and their correlation with serum concentrations in Welsh ponies with equine metabolic syndrome
Katarzyna Basinska, Krzysztof Marycz, Agnieszka ?mieszek, Jakub Nicpo? 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 1호 15 113-120 (8 pages)
A main symptom of equine metabolic syndrome (EMS) in ponies is pathological obesity characterized by abnormal accumulation of fat deposits and inflammation. In this study, we analyzed the expression of two pro-inflammatory cytokines, interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), in subcutaneous adipose tissue and the correlation with serum concentrations in peripheral blood of Welsh ponies. Based on clinical examination findings, the animals were... -
The Neuroprotective Potential of Cyanidin-3-glucoside Fraction Extracted from Mulberry Following Oxygen-glucose Deprivation
MohammadIqbalHossainBhuiyan, Hyun-BokKim, SeongYunKim, Kyung-OkCho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.6 6 353-362 (10 pages)
In this study, cyanidin-3-glucoside (C3G) fraction extracted from the mulberry fruit (Morus alba L.) was investigated for its neuroprotective effects against oxygen-glucose deprivation (OGD) and glutamate-induced cell death in rat primary cortical neurons. Cell membrane damage and mitochondrial function were assessed by LDH release and MTT reduction assays, respectively. A time-course study of OGD-induced cell death of primary cortical neurons at 7 days in vitro (DIV) indicated that neuronal... -
Cisplatin-induced Alterations of Na+-dependent Phosphate Uptake in Renal Epithelial Cells
SungJuLee, ChaeHwaKwon, YongKeunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.2 5 71-77 (7 pages)
of phosphate transporter in membranes were evaluated by kinetic analysis, [14C]phosphonoformic acid binding, and Western blot analysis. Cisplatin inhibited phosphate uptake in a time- and dose-dependent manner, and also the Na-dependent uptake without altering Na-independent uptake. The cisplatin inhibition was not affected by the hydrogen peroxide scavenger catalase, but completely prevented by the hydroxyl radical scavenger dimethylthiourea. Antioxidants were ineffective in... -
Baicalein Protects 6-OHDA-induced Neuronal Damage by Suppressing Oxidative Stress
Heh-InIm, EunjooNam, Eun-sunLee, Yu-jinHwang, YongSikKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.6 3 309-316 (8 pages)
The protective effects of baicalein, one of the flavonoids in Scutellaria baicalensis Georgi, were evaluated against 6-hydroxydopamine (6-OHDA)-induced neuronal damage in mice and cultured human neuroblastoma cells. Nigrostriatal damage was induced by stereotaxically injecting 6-OHDA into the right striatum. Baicalein was administered intraperitoneally 30 min before and 90 min after lesion induction. Animals received a further daily injection of baicalein for 3 consecutive days. Two weeks after... -
Estrogen Pretreatment of Organotypic Hippocampal Slices Protects Neurons against Oxygen-Glucose Deprivation with Akt Activation
Eun-MiPark, SunghuiHong, Kyung-EunLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.3 2 123-130 (8 pages)
In several experimental models, estrogens protect neurons against ischemic insults. However, the recent clinical studies of hormone replacement showed negative results to prevent stroke. Therefore, optimal models to study estrogen replacement for neuroprotection are needed before its clinical application. Organotypic hippocampal slice under oxygen-glucose deprivation (OGD) has been established as a model of cerebral ischemia and has advantages to study drug effects. We investigated whether... -
Inhibition of NF-κB Activation Increases Oxygen-Glucose Deprivation-Induced Cerebral Endothelial Cell Death
JinuLee, ChulHoonKim, KyuDaeShim, YoungSooAhn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.2 3 65-71 (7 pages)
Increasing evidences suggest that ischemia-induced vascular damage is an integral step in the cascade of the cellular and molecular events initiated by cerebral ischemia. In the present study, employing a mouse brain endothelioma-derived cell line, bEnd.3, and oxygen-glucose deprivation (OGD) as an in vitro stroke model, the role of nuclear factor kappa B (NF-κB) activation during ischemic injury was investigated. OGD was found to activate NF-κB and to induce bEnd.3 cell death in a... -
Changes in Phosphate Transporter Activity Evaluated by Phosphonoformic Acid Binding in Cadmium-Exposed Renal Brush-Border Membranes
JinMoChung, DoWhanAhn, KyoungRyongKim, YangSaengPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.5 8 513-519 (7 pages)
in phosphate (Pi) transport capacity. Biochemical mechanism of this reduction was investigated in the present study. Renal proximal tubular brush-border membrane vesicles (BBMV) were isolated from rabbit kidney outer cortex by Mg precipitation method. Vesicles were exposed to 50∼200 μM CdCl2 for 30 min, then the phosphate transporter activity was determined. The range of Cd concentration employed in this study was comparable to that of the unbound Cd documented in renal cortical tissues of... -
Role of Phospholipase A2 in Oxidant-induced Alteration in Phosphate Transport in Primary Cultured Rabbit Renal Proximal Tubule Cells
KwonMooPark, SunHeeKo, JaeSukWoo, JinSupJung, SangHoLee, YongKeunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.5 8 601-609 (9 pages)
The present study was undertaken to examine the role of phospholipase A2 (PLA2) in oxidant-induced inhibition of phosphate transport in primary cultured rabbit renal proximal tubule cells. Uptakes of phosphate and glucose were dose-dependently inhibited by an oxidant t-butylhydroperoxide (tBHP), and the significant inhibition appeared at 0.025 mM of tBHP, whereas tBHP-induced alterations in lipid peroxidation and cell viability were seen at 0.5 mM. tBHP stimulated arachidonic acid (AA) release... -
Effect of Bromocriptine on 6-Hydroxydopamine-induced Lipid Peroxidation and Cytotoxicity in vitro and in vivo
YongSikKim, SunghoMaeng, ChanWoongPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.5 4 565-572 (8 pages)
The present study was to evaluate the protective effects of bromocriptine, which is known as D2 dopamine receptor agonist and used for the treatment of patients with Parkinson's disease (PD), on 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in vitro and in vivo. Lipid peroxidation product (malondialdehyde; MDA) produced by the administration of 6-OHDA was profoundly reduced following the treatment of bromocriptine in a dose-dependent manner in rabbit brain homogenate. Quinone formation by... -
Analysis of protein expression in Brucella abortus mutants with different growth rates by two-dimensional gel electrophoresis and LC-MS/MS peptide analysis
Woo Bin Park, Young Bin Im, Soojin Shim, Han Sang Yoo 대한수의학회 Journal of Veterinary Science 16 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 2호 8 216-231 (16 pages)
Brucella abortus is a bacterium that causes brucellosis and is the causative agent of worldwide zoonoses. Pathogenesis of the B. abortus infection is complicated, and several researchers have attempted to elucidate the infection mechanism of B. abortus. While several proteins have been revealed as pathogenic factors by previous researchers, the underlying mechanism of B. abortus infection is unresolved. In this study, we identified proteins showing different expression levels in B. abortus... -
Differential Expression of Metabolism-related Genes in Liver of Diabetic Obese Rats
EunhuiSeo, Eun-JinPark, Mi-KyoungPark, DukKyuKim, Hye-JeongLee, Sook-HeeHong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.2 6 99-103 (5 pages)
The Otsuka Long-Evans Tokushima Fatty (OLETF) rat, a model of spontaneous type 2 diabetes (T2D), develops hyperglycemic obesity with hyperinsulinemia and insulin resistance after the age of 25 weeks, similar to patients with noninsulin-dependent diabetes mellitus (DM). In the present study, we determined whether there are differences in the pattern of gene expression related to glucose and lipid metabolism between OLETF rats and their control counterparts, Long-Evans Tokushima (LETO) rats. The... -
Colletotrichum gloeosporioides에 대한 Bacillus licheniformis IUB066-22의 항진균활성
김혜영, 이혜자, 김남정 한국보건기초의학회 한국보건기초의학회지 9 Pages
한국보건기초의학회 한국보건기초의학회지 2013, Vol.6 No.2 8 101-109 (9 pages)
-
Selection of Reference Genes for Real-time Quantitative PCR Normalization in the Process of Gaeumannomyces graminis var. tritici Infecting Wheat
Li-hua Xie, Xin Quan, Jie Zhang, Yan-yan Yang, Run-hong Sun, Ming-cong Xia, Bao-guo Xue, Chao Wu, Xiao-yun Han, Ya-nan Xue, Li-rong Yang 한국식물병리학회 The Plant Pathology Journal 8 Pages
한국식물병리학회 The Plant Pathology Journal 2019, 35권 1호 2 11-18 (8 pages)
Gaeumannomyces graminis var. tritici is a soil borne pathogenic fungus associated with wheat roots. The accurate quantification of gene expression during the process of infection might be helpful to understand the pathogenic molecular mechanism. However, this method requires suitable reference genes for transcript normalization. In this study, nine candidate reference genes were chosen, and the specificity of the primers were investigated by melting curves of PCR products. The expression... -
Profiling of Disease-Related Metabolites in Grapevine Internode Tissues Infected with Agrobacterium vitis
한국식물병리학회 The Plant Pathology Journal 11 Pages
한국식물병리학회 The Plant Pathology Journal 2016, 32권 6호 1 489-499 (11 pages)
Green shoot cuttings of 10 different grapevine species were inoculated with Agrobacterium vitis to find disease-related metabolites in the grapevine. Crown galls formed 60 days after inoculation varied in gall severity (GS) evaluated by gall incidence (GI) and gall diameter (GD), which were classified into three response types as RR (low GI and small GD), SR (high GI and small GD), and SS (high GI and large GD), corresponding to resistant, moderately resistant, and susceptible responses,... -
Involvement of Heme Oxygenase-1 in Orexin-A-induced Angiogenesis in Vascular Endothelial Cells
Mi-KyoungKim, Hyun-JooPark, , Su-RyunKim, , YoonKyungChoi, Soo-KyungBae, Moon-KyoungBae 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.4 4 327-334 (8 pages)
The cytoprotective enzyme heme oxygenase-1 (HO-1) influences endothelial cell survival, proliferation, inflammatory response, and angiogenesis in response to various angiogenic stimuli. In this study, we investigate the involvement of HO-1 in the angiogenic activity of orexin-A. We showed that orexin-A stimulates expression and activity of HO-1 in human umbilical vein endothelial cells (HUVECs). Furthermore, we showed that inhibition of HO-1 by tin (Sn) protoporphryin-IX (SnPP) reduced... -
Induction of Heat Shock Proteins and Antioxidant Enzymes in 2,3,7,8-TCDD-Induced Hepatotoxicity in Rats
Hyun-SookKim, So-YoungPark, Ki-YeolYoo, SeungKwanLee, Woon-WonJung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.6 14 469-476 (8 pages)
2,3,7,8-Tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) is an environmental toxicant with a polyhalogenated aromatic hydrocarbon structure and is one of the most toxic man-made chemicals. Exposure to 2,3,7,8-TCDD induces reproductive toxicity, immunotoxicity, and hepatotoxicity. In this study, we evaluated how 2,3,7,8-TCDD-induced hepatotoxicity affect the expression of heat shock proteins and antioxidant enzymes using the real-time polymerase chain reaction (PCR) in rat. 2,3,7,8-TCDD increased heat... -
고압산소 전처치의 섬근 항산화효소 활성 증가 및 허혈-재관류손상 보호 효과
오동진, 김영훈, 김찬형, 박종완, 김명석 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.6 16 749-758 (10 pages)
Pretreatment of Hyperbaric Oxygenation Increases the Activities of Myocardial Antioxidant Enzymes and Protects the Ischen뻐-Reperfusion Injury of the Heart. Dong Jin OhI， Young-hoon Kim， Chan-hyung Kim， Jong-wan Park， and Myung-suk Kim lDepartment of Intemal Medicine， Gangdong Sacred Heaπ Hospital， College of Medicine， Hallym University; Department of Phannacology， College of Medicine， Seoul N ational University， Seoul 110 -799， Korea -
Role of Na+-K+ Pump on Endothelium-dependent Relaxation
Sung, Sang-Hyun, Roh, Joon-Ryang, Park, Tae-Sic, Suh, Suk-Hyo, Hwang, Sang-Ik, Kim, Ki-Whan 대한생리학회 대한생리학회지 10 Pages
대한생리학회 대한생리학회지 1993, 제 27권 제 2호 8 199-208 (10 pages)
To study the underlying mechanism through which the endothelium-dependent relaxation is inhibited by blocking the Na+ -K+ pump, the effects of Na+ -K+ pump blockade on the release of EDRF and its relaxing activity were examined, using organ bath study, bioassay technique, and cGMP measurement. Endothelium-dependent relaxation was attenuated by blocking the Na+ -K+ pump in the vascular ring with intact endothelium. In bioassay experiment EDRF release was decreased with the blockade of the Na+...
