The preparation of bismuthsubnitrate for the purpose of medicine, with both crude and refined bismuth metals, has been performed by applying the following methods: (A) Neutralization process, (B) Hydrolysis process. On the basis of results of a series of experiments, the following conclusion was obtained: 1) The quantitative determination showed that there was little difference between these two processes, in their yields. However the process (B), hydrolysis method was technically more simple than (A), neutralization method, and purity of final product by process (B) was found to be much more superior to (A). 2) It was found that bismuthsubnitrate products obtained from refined bismuth metal was almost the same with imported ones (Fisher, Squibb, etc.) in their purities.