Many of the studies on absorption and excretion of drugs have been reported in the field of pharmaceutics, but the effect of acrid condiments for the absorption of drugs has not been. Hereupon, the authors investigated them in small intestine canal of rat in situ. In this experiment, aminopyrine, sulfadiazine and salicylic acid appended acrid condiments such as garlic, red pepper and pepper showed more increased absorption than constituted drugs. In particular, pepper showed the most increased than pepper, red pepper and garlic take lower absorption than pepper. When two drugs and over exist at a time, the efficacy is different from each other. Therefore, it is necessary to research of each circumstances administering one drug or compound drugs. We considers that we are abet to get safe and effectivecopound preparations when we studies on the effect. of drug action.