Three patients with multiple occurance of Gargoylism in a family who were admitted to Kyungpook National Univ. Hospital were observed. Two cases were siblings and another one was maternal relative with sex linked recessive inheritance. Diagnosis of cases were made by laboratory findings of Gargoyle cells in bone marrow and excessive excretion of mucopolysaccharide in the urine. Charactristic skeletal radiologic findings of three gargoylisms were discussed.