The effects of the ether extract of Zizyphi spinosi semen and lithium chloride on the serum ceruloplasmin level in blood of rabbits were examined. An oral dose 1gm/kg/day of the ether extract and oral dose of lithium chloride 1 Meq/kg/day with 1gm/kg/day of the ether extract were administered respectively to rabbits for eight days, The results are: 1)Serum ceruloplasmin level in blood of the rabbits treated with the ether extract was higher than that of the control group. 2)The level of the rabbits treated with both the ether extract and lithium chloride was higher than that of the control. 3)The administration of lithium chloride alone also increased ceruloplasmin blood level.