The purpose of this study was to obtain the cephalometric maxillofacial soft tissue measurements, and to define the differences that exist between males and females on the soft tissue profile who had normal occlusion in mixed dentitions. For the object of this study, cephalometric radiographs were obtained from the centric occlusion with the relaxed lip position. Copper filter was designed to obtain both hard and soft tissue structure on the same film. The subjects consist of 100 males and 100 females from 8 to 12.4 years with the normal occlusion and acceptable profiles. The author measured facial depth, vertical height from the tissue profiles in the mixed dentitions. The significant test compare males with females. The following results were obtained from the study 1. In facial convexity, much more larger females than that of males. 2. Inclination of the lip posture were more larger in maxilla (male) and in females more larger in the mandible. 3. The thickness of soft tissue were thicker in males, the height of nose were more prominent in females. 4. There were no significant differences in both sexes.