- ${alpha}$-Bromophenylacetamide의 가수분해 반응연구
- ㆍ 저자명
- 김인규,윤용진,Kim. In Kyu,Yoon. Young Jin
- ㆍ 간행물명
- 대한화학회지
- ㆍ 권/호정보
- 1978년|22권 5호|pp.334-339 (6 pages)
- ㆍ 발행정보
- 대한화학회
- ㆍ 파일정보
- 정기간행물| PDF텍스트
- ㆍ 주제분야
- 기타
${alpha}$-Bromophenylacetamide를 황산중에서 가수분해시키면 대개의 경우 mandelic acid와 ${alpha}$-bromophenylacetic acid의 혼합물이 얻어지고, 염산의 경우에는 ${alpha}$-chlorophenylacetic acid만이 얻어졌다. 그러나 조건을 잘 조절하면 mandelic acid와 ${alpha}$-chlorophenylacetic acid는 각각 86, 95 % 이상의 좋은 수율로 순수하게 생성되지만, ${alpha}$-bromophenylacetic acid만을 순수하게 생성시키는 최적 조건은 찾지 못하였다. 즉 이들 조건에서 ${alpha}$-탄소의 브롬이 각각 $OH^{Theta}$ 와 $Cl^{Theta}$로 쉽게 치환되었다.
The hydrolysis of ${alpha}$-bromophenylacetamide in the acidic media has been studied. The reactions in sulfuric acid and p-toluenesulfonic acid afforded mainly mandelic acid ; on the other hand, in hydrochloric acid ${alpha}$-chlorophenylacetic acid was the main product. In either case, it was difficult to obtain ${alpha}$-bromophenylacetic acid without concomittant formation of mandelic acid and ${alpha}$-chlorophenylacetic acid respectively from the hydrolysis of ${alpha}$-bromophenylacetamide. Mandelic acid and ${alpha}$-chlorophenylacetic acid were obtained in good yields (86, 95 %) in sulfuric and hydrochloric acid respectively; the reactions are therefore potentially useful processes for obtaining them.