L-tryptophan을 백서 복강내 과량 (0.34m mole) 투여시 간장내 지방축적에 있어서 호르몬의 작용을 관찰한 바 부신적출한 백서에서 Epinephrine과 L-tryptophan 동시주사군이 Epinephrine 단독주사군에 비하여 1.5배의 증가를 보이고 혈액내 유리지방산의 농도도 높으나 그외의 다른 호르몬(Hydrocortisone, Glucagon, Insulin)은 간장조직내 지방축적에 아무 작용도 없었다.
When an excess amount of L-tryptophan (0.34mmole) was administered intraperitioneally to a normal rat the triglyceride content in the liver increased two times that of the normal control in three hours, but no significant changes of triglyceride content in the liver of adrenalectomized rat was noted, however, the triglyceride content in liver and FFA in the plasma of adrenalectomized rat administered epinephrine and L-tryptophan together was increased as much as one and a half times than that of the control adrenalectomized rat which received L-tryptophan or epinephrine only. No effects of hydrocortisone, glucagon and insulin on the triglyceride accumulation in the liver were noted in adrenalectomized rat receiving each hormone or L-tryptophan only, or hormone and L-tryptophan together. Therefore, it was confirmed that the triglyceride accumulation in the liver induced by L-tryptophan is due to the indirect effect of L-tryptophan through stimulation of epinephrine secretion.
