A Tc-99m sulfur colloid hepatic scintigraphy is often the first imaging modality empolyed in the evaluation of the patient with suspected liver disease, since the hepatic scintigraphy is not only highly sensitive, low expense and easy of performance but also provides both sturctural and functional information of the liver. The author analyzed the scintigraphic finding in 304 patient proven various hepatic disease and 58 normal liver, and also retrospectively analyzed the result of hepatic scintigraphy and ultrasonography of the liver in 117 patients. The results were as follows: 1. The overall sensitivity and specificity of hepatic scintigraphy in the liver disease is 91% and 67%, respectively. 2. On the evaluation of the diffuse parenchymal parenchymal disease of liver, the scintigraphy was found to be highly sensitive (88%) and also specific image patteerns were found in cirrhosis. 3. The hepatic scintigraphy was highly sensitive (92%) in the detection of the focal lesions of liver. 4. The ultrasonography was capable of differentiating solid and cystic masses which were detected on scintigraphy, while scintigraphy was more sensitive in detection of hepatocellular disease. 5. Tc-99m sulfur colloid imaging remained the preferred inital screening method in patients with suspected liver disease, while ultrasonography should be done for those patients with a prior suspicious findings.