In this paper, we define the z-S-closed spaces using the notions of zero-sets and S-closed spaces introduced by T. Thompson, and investigate some properties of these spaces. We also obtain the following results. If a space X is z-S-closed, then every cover of z-regular semiopen sets has a finite proximate subcover. A z-extremally disconnected z-QHC space is z-S-closed, z-S-closed is contagious.