Synthesis of ($Tyr^5$), ($Tyr^8$), ($Tyr^5$, $Tyr^8$) and ($Trp^8$) analogues of bradykinin was carried out by solid phase method. The yield range from 58.6 to 68.2% owing to an improved reaction vessel. Coupling was performed by dicyclohexylcarbodiimide. After cleavage with dried HBr the peptides were purified by Sephadex G-25 and carboxymethyl cellulose chromatography. Their purity was assessed by paper and thin layer chromatography, melting point, amino acid analysis and biological assay. The effect of blood pressure depression in rat by ($Try^8$) bradykinin was about 1.3 times as that of bradykinin, the standard. ($Tyr^5$), ($Tyr^8$), ($Tyr^5$, $Tyr^8$) and ($Trp^8$) analogues of bradykinin were incubated in vitro with endopeptidase ($alpha$-chymotrypsin) and exopeptidase (carboxypeptidase A, leucine aminopeptidase) in order to study the degradation patterns of peptides. Four bradykinin analogues were rapidly degradated by $alpha$-Chymotrypsin and carboxypeptidase A, while the degradation by leucine aminopeptidase is slow.