- Flurbiprofen 용매침착물(溶媒沈着物)의 용출특성(溶出特性)에 관(關)한 연구(硏究)
- ㆍ 저자명
- 최보경,용재익,Choi. Bo-Kyung,Yong. Jae-Ick
- ㆍ 간행물명
- 藥劑學會誌
- ㆍ 권/호정보
- 1985년|15권 3호|pp.100-112 (13 pages)
- ㆍ 발행정보
- 한국약제학회
- ㆍ 파일정보
- 정기간행물| PDF텍스트
- ㆍ 주제분야
- 기타
Dissolution characteristics of flurbiprofen solvent deposited on ${alpha}-cyclodextrin$, ${eta}-cyclodextrin$, lactose and corn starch were studied to evaluate the pharmaceutical aspects of solvent deposition method where drug was solvent deposited on the surface of excipients. In a solvent deposition system, the drug to excipient ratio and kind of excipient affect much on dissolution rates of flurbiprofen. The solvent deposition system formation was confirmed by scanning electron microscope. By increasing the amounts of matrix, it was possible to enhance the dissolution rate of flurbiprofen solvent deposition system. The amount of flurbiprofen dissolved from ${eta}-cyclodextrin$ deposition system (1:10) at 60 minutes was enhanced 6.5 times in water and 28 times in simulated gastric juice compared with flurbiprofen alone. Flurbiprofen solvent deposited system (1:10) enhanced dissolution rate greater than inclusion complex and dispersion system.