Percutaneous biopsy is the most frequent interventional radiographic procedure. Its increased use is related to new imaging techniques facilitating needle placement, greater safety of fine needle and advances in cytology. Computed Tomography(CT), becauses of its characteristic high spatial and denisty resolution, permits the accurate localization of any lesion in the boldy. Because of the ability of CT scans to precisely localize lesions and biopsy needle, along with the delineation of aduacent structures, it is widely used in percutaneous biopsy. Sixty-six cases of CT-guided percutaneous fine-needle biopsy were performed in order to diagnose suspected malignant or infectious diseases(49malignant and 17 infectious) over a 7-month period(June 1984 through December 1984). Most of these procedures were performed on, but not limited to, the lung(21), liver(20), and pancreas(7). The spine and nasopharynx could also safely be biopsied. 4 cases of heaptic abscesses were successfully rained following insertion of draining catheter under the CT-guidance. The overall accuracy of both suspected malignant and infectious diseases was 82%. Complication rate was low as 6%(4cases only in thorax). Neither complication require any further intervention. Three were self-limited pneumothoraces and one was minimal hemorrhage around the needle tract.