The purpose of this study was to investigate whether or not $VATAMIN B_1$ (thiamin hydrochloride) could prevent and/or treat lead posoning in rats. Sprague-Dawley used in this experiment were divided into three group; control group compound group (thiamin 10mg+0.4% lead acetate solution) lead group (0.4% lead acetate solution). The results obtained were summarized as follow; 1. The body weight gain of treated groups (compound group and lead group) were lowered significantly in comparsion with those of control groups (p<0.01). But the significant difference between treated group was not observed (p<0.05).