The authors reviewed 104 cases of SPECT liver image performed at Soonchunhyang Univ. Hospital from August 1985 to July 1986, and compared with ultrasonographic finding of 87 cases of same patients. We also analyzed liver phantom image by SPECT compared with gamma camera static scan for experiental study. RESULT : 1. 9mm sized small lesions are detected by SPECT, which are regrdless of depth in experimental study. 2. The cold defct of lesions and normal structure of liver which cannot be differentiated in gamma camera static scan is well diagnosed by SPECT. 3. The location and vloume of lesions can be relatively well calculated by SPECT. 4. The accuracy of focal liver diseases is 91.5% in SPECT and 87.3% in ultrasonography. 5. The sensitivity and specificity of SPECT are 90.9% in focal liver diseases and 75.9%, 80.8% in diffuse parenchymal liver diseases. The diagnostic value of spect in liver diseases will be increased as the improved quality of image according.