Stress intensity factors for the bimaterial interface cracks are determined by the boundary element method employing the multiregion technique along with the double-point concept. For this purpose, the formulas relating the stress intensity factors to the crack surface displacements, which are applicable to both the homogeneous and the bimaterial systems, are derived and the accuracy of the results is discussed using the preexisting analytic solutions. Besides, the stress intensity factors for the edge-cracked bimaterial plates are computed with various crack lengths and shear modulus ratios under the biaxial and the uniaxial loadings, respectively, to demonstrate the dependence of stress intensity factors on the loading conditions and the material properties.