The purpose of this study was to examine the effect of therapeutic instrument music playing on hand grasp strength and dexterity in stroke patients. The subjects of this study were three outpatients(two men and a woman) who were being treated in the department of rehabilitation medicine of **University Hospital due to hemiplegia caused by stroke. Aiming at them, music treatment was conducted for 4 weeks from September 22 to October 22, 2005, 20 sessions in total(five times a week, 30 minutes per session). The researcher applied multiple baseline design between the subjects for this study and dynamometer, box, and block test were used to measure hand grasp strength and dexterity. After the each session was completed, the affected and unaffected results were recorded with two other observers. As a result of this study, an improvement showed in hand grasp strength and dexterity of affected and unaffected of the three subjects as therapeutic instrument music playing intervention was developed. Specially, it can be noted that three subjects showed high scores when preferred songs and instruments were used and improvisation method showed effects. Also, disease duration and number of sessions showed a close relationship and the shorter disease duration was, the more effects showed in the early stage of the sessions.