This study was carried out to investigate effects of Kalopanaxii Cortex extract(K. C. E,) on $CCI_4$-induced liver damage in rabbits and acute toxicity in mice. 1. $LD_{50}(mg/kg)$ of K. C. E. was 7.3g/kg by intraperitoneal administration in mice. 2. K. C. E. groups showed more rapid recovery than the control group in $CCI_4$-intoxicated rabbits and 800mg/kg was the most effective. 3. SGPT and alkaline phosphatase activity showed and apparent decreasing effect within 14 days and 2 days respectively in 800mg/kg. 4. The levels of total cholesterol and total bilirubin showed and apparent decreasing effect within 10 days and 6 days respectively in 800mg/kg. It is suggested that K. C. E. can be administered not only as a therapeutic agent but also a healthy food to shorten the recovery time of hepatic function in liver diseases.