Percutaneous alcohol injection(PAI) is a new sclerosing method for treatment of diseases such as cyst malignant tumor and benign neoplasm. Percutaneous alcohol injection of 26 cases (adenomatous goiter 23 cases follicular adenoma 2 cases & recurrent papillary carcinoma 1 cases) of thyroid nodules were done with 23-G needle under the guidance of ultrasonography. After then we followed up thyroid function test ultrasonographical size and volume of nodules cytologic examination and complications of treatment. The results were as follows: 1. With 0.5-1cc alcohol injection the mean volumes of thyroid nodules were reduced after PAI to 59% (N=26) at 1 month and to 33% (N=14 cases of additiohal PAI) at 6 months of the base line volume (100%) before PAI. 2. There were no significant changes at 1 and 6 months follow-up of TFT after PAI in all cases as compared with base line studies 3. In conclusion ultrasonic guided PAI for thyroid nodule is simple useful and cost-effective method and recommendable in cases of mixed and solid nodules resistant to medical treatment refusal of surgery because of cosmetic problem and recurrent malignant tumors.