The climacterium is that phase in the aging precess during which a woman passes from the reproductive to the non-reporductive stage. The signals, such as hot flashes, vaso-motoric disturbances, perspiration, stiff shoulders, emotinal symptoms, are refered to as climacteric disturbances. Treatment of climacteric symptoms centers around estrogen replacement and transfuilizers, but there are many problems to be solved to use these hormones/drugs as far as dossage, duration and complications are concerned. The care of women during the climacteric years should provide relief of distressing symptoms with as high a degree of safety as possible. From this view point, we used red ginseng powder to those patients with high menopausal index successfully. We studied its mechanism of action and proved that red ginseng improved the micro-circulation system via improvement of erythrocyte reformability which enhanced sex steroidgensis consequently.