To evaluate sequential radiological changes and detectability of various radiological modalities in hematogeneous pulmonary metastasis we performed an experimental study by using VX-2 carcinoma in rabbits. hematogeneous pulmonary metastasis was induced by injecting suspension of VX-2 carcinoma through the vein of the ear. Five rabbits in each group were sacrificed after 3, 7, 14, 21 and 30 days of injection. sequential follow-up chest radiography in vivo state and soft tissue radiography, high resolution CT, microradiography of the inflated and fixed lungs were done. Gross pathological and radiological evidence of pulmonary metastasis were seen in all rabbits sacrificed after 21 days. Chest radiographic evidence of pulmonary metastasis began to appear after 14 days of injection and showed well defined nodules abut 4mm in diameter. high resolution C of the inflated and fixed lung showed metastatic nodules at 7 th day of injection as tiny nodule about 1mm in diameter. Besides th nodules, HRCT and microradiography showed clearly peribronchovascular and perinodular lymphangitic tumor spread in all five rabbits sacrificed after 30 day. In conclusion, even with a guinuine hemotogeneous pulmonary metastasis, lymphangitic metastasis is associated in late stage of the disease and HRCT provides early detection of the nodules.