Intra-arterial Chemotherapy (IAC) was performed to the 34 patients with nonmetastatic osteosarcoma using Cisplatin and surgery was done in 26 cases out of 34. We analysed the therapeutic effect of IAC in the view of local control rate and distant metastasis for two and half years. local control rate was 94% on the base of the radiologic studies including simple X-ray, angiography and CT. No viable cells were observed in 50% of the cases on the pathologic examination of the surgical specimens. Distant metastasis developed in 14 cases 9415) , mainly in the lung, No significant complications occurred except each case of acute renal failure, congestive heart failure and peripheral embolism, which were improved by proper management. IAC is one of the most effective methods in controlling the regionally confined osteosarcoma, but it may be incorperated with other adjuvant protocols to decrease the chance of delayed metastasis.