[ $^{111}$ ]In has wide applications in nuclear medicine for labelling and in-vivo distribution studies. A method is developed for the production of carrier free $^{111}$In using the reaction $^{nat.}Cd(p,;xn)$ $^{111}$In with MC-50 cyclotron. Carrier free $^{111}$In was separated from the irradiated metallic cadmium by liquid-liquid extraction and cation exchange chromatography. The yield of $^{111}$In at EOB is $0.8mCi/{mu};Ahr$ and the nuclidic purity is over 99%. $^{111}In-DTPA;and;^{111}In-bleomycin$ were prepared for medical study.