This study was conducted to provide information of effective student guidance in nursing education. The sample consisted of 103 nursing students in the area of Seoul and 143 students in Cholla Province. Data were collected by using a questionnaire, which consisted of items about personnal campus life and their major. The results are summarized as follows: 1. There was on significant difference in campus life adaptation on nursing students between Seoul and local areas. 2. In Seoul area, there was no significant difference in campus life adaptation according to academic years. In local area, significant difference was revealed in the academic years. The scores of campus life adaptation were possitively correlated with their academic years. 3. The variables which can be explained in the regional difference were social recognition of nursing and a family atmosphere. In conclusion, the results of the study indicate that, in Seoul and local areas, the personal and educational backgrounds of campus life adaptation were equalized. In addition, it is very important that the counselling on choice of major should be provided to high school students.