The synthetic methodologies for the preparation of C-nucleosides are divided into four categories, and each category is discussed in details. The chemical rections which lead to other C-nucleosides from preformed the natural product pseudouridine are described first, followed by synthesis of C-nucleosides by condensation of pre-formed heterocyclic base with sugar, and by construction of heterocyclic base from a carbohydrate intermediate that bear functional carbon fragment at the anomeric position. Finally, methods of total synthesis of C-nucleosides from carbohydrate and achiral starting materials are presented.