Prodrugs of flurbiprofen, 1,2-ethanediolester(FE) and 1,4-butanediolester(FB) were prepared and their biopharmaceutical studies were performed. The prodrugs showed high stability in simulated gastric fluid, simulated intestinal fluid and pancreatin-saturated solution. Pharmacokinetic parameters of the prodrugs were similar to those of their parent drug. However they showed less acute toxicity and gastric irritation and higher anti-inflammatory and analgesic effects.