합성된 2-chloroethyl acrylate를 출발물질로 이용하여 5-fluorouracil의 $N_1$-위치에 각각 hydroxyethyl, acryloyloxyethyl, poly(acryloyloxyethyl)기를 가진 5-fluorouracil 유도체를 높은 수율로 얻었다. 이들 유도체들과 HCl과의 가수분해속도를 물-에탄올(1:1) 혼합용매에서 UV 분광기를 이용하여 측정하였다. 1-hydroxyethyl-5-fluorouracil, 1-acryloyloxyethyl-5-fluorouracil 및 Poly(1-acryloyloxyethyl-5-fluorouracil)의 가수분해속도는 각각 $k=1.38{ imes}10^{-4}$sec, $9.25{ imes}10^{-5}$/sec, $4.16{ imes}10^{-5}$/sec 이었다. 또한, 합성된 5-fluorouracil 유도체의 열분해성에 대해 논의하였다.
$N_1-alkyl-5-fluorouracil$ derivatives from 2-chloro-ethylacrylate(CEA) were synthesized. The reaction of 5-fluorouracil(5-FU) with 2-chloroethyl acrylate gave 1-hydroxyethyl-5-fluorouracil(HEFU) in 70% yield. The treatment of HEFU with acryloyl chloride afforded 1-acryloyloxyethyl-5-fluorouracil (AOEFU). Poly(1-acryloyloxyethyl-5-fluorouracil)[Poly(AOEFU)] was also synthesized from 5-fluorouracil and Poly(CEA). The hydrolysis rates of $N_1-alkyl-5-fluorouracil$ derivatives were observed by means of UV spectrophotometer at 265 nm in ethanol-water(1 : 1); k = the constant of hydrolysis rate, $k=1.38{ imes}10^{-4}$/sec for HEFU, $k=9.25{ imes}10^{-5}$/sec for AOEFU, $k=4.16{ imes}10^{-5}$k = 4.16 ${ imes}$ $10-5}sec$ for Poly(AOEFU). The differential thermal analysis and thermogravimetry of 5-fluorouracil derivatives have been discussed.
