- 2-(p-메틸알릴아미노페닐)프로판산의 합성
- ㆍ 저자명
- 최홍대,윤호상,강병원,마정주,손병화,Choi. Hong-Dae,Yun. Ho-Sang,Kang. Byung-Won,Ma. Jung-Joo,Son. Byeng-Wha
- ㆍ 간행물명
- 약학회지
- ㆍ 권/호정보
- 1992년|36권 1호|pp.12-16 (5 pages)
- ㆍ 발행정보
- 대한약학회
- ㆍ 파일정보
- 정기간행물| PDF텍스트
- ㆍ 주제분야
- 기타
A new method for the synthesis of alminoprofen, which is a non-steroidal antiinflammatory agent, was described. Ethyl 2-phenyl-propionate(4) was prepared by Friedel-Crafts reaction of benzene with ethyl ${alpha}-chloro-{alpha}(methylthio)acetate(1)$, followed by methylation and desulfurization of the resultant ethyl 2-(methylthio)phenylacetate(2). Ethyl 2-(p-aminophenyl)propionate(6) was obtained by nitration of (4) and successive reduction of ethyl 2-(p-nitrophenyl)propionate(5). Alminoprofen was synthesized by reaction of (6) with methallyl chloride, followed by hydrolysis of the resultant ethyl 2-(p-methylallylaminophenyl)propionate (7).