An elasto-plastic-damage constitutive model for ductile materials was derived under the framework of thermodynamic approach of contimuum damage mechanics(CDM) in which internal irreversible thermodynamic change of micro-structure of materials such as plastic deformation and damage evolution were considered as thermodynamic state variables. New constitutive model can predict not only the elasto-plastic behaviors but also the sequential degradation process of ductile materials more rationally.