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급성 및 만성 B형 간염환자의 위배출시간에 관한 연구
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  • 급성 및 만성 B형 간염환자의 위배출시간에 관한 연구
  • Gastric Emptying Time in Acute and Chronic Hepatitis B Patients
저자명
이경한,김호정,추길연,김정한,김재명,원종현,박권택,김승욱,Lee. Kyung-Han,Kim. Ho-Jong,Choo. Kil-Yeon,Kim. Jung-Han,Kim. Jae-Myung,Won. Chong-Hyun,Park. Gw
간행물명
大韓核醫學會誌
권/호정보
1992년|26권 2호|pp.307-311 (5 pages)
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대한핵의학회
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정기간행물|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

Anorexia, nausea, and vomiting are one of the most frequent symptoms in viral hepatits patients. These may be due to poorly detoxified substances by dysfunctioned hepatocytes or by gastritis, but the pathophysiology is not totally understood. The symptoms interfere with adequate nutrient intake and are managed by metoclopramide, which accelerates gastric emptying. Thus delayed gastric emptying may well be a contributing factor to such symptoms. To determine such a relationship, we measured gastric emptying time in 11 normal subjects,9 acute (AVH), and 12 chronic B viral hepatitis (CVH) patients. All were males with a mean age of 23 years. An egg was labeled with 0.5 mCi of $^{99m}Tc-sulfur$ colloid, fried, then eaten between 2 slices of bread with 100 cc of water. Anterior and posterior images were taken at 20 minute intervals over a 2 hour period. A geometric mean of activity pertaining to the gastric region was measured, and $T_{1/2}$ was calculated from the time activity curve. $T_{1/2}$ for normal the group was $57.8{pm}6.3$ minutes while that for the AVH and CVH group was $58.2{pm}8.2$ (p=0.40) and $64.1{pm}10.5$ (p=0.09), respectively. There was 1 AVH Patient and 4 CVH patients with prolonged $T_{1/2}$. Anorexia and nausea was seen in 71% and 46% of the patients, respectively. 80% and 60% of the patients with prolonged $T_{1/2}$ had anorexia and nausea, respectively.