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Fibrinolytic and Cogulation Activities of Korean Snake Venoms
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  • Fibrinolytic and Cogulation Activities of Korean Snake Venoms
  • Fibrinolytic and Cogulation Activities of Korean Snake Venoms
저자명
Chung. Kwang-Hoe,Kim. Doo-Sik
간행물명
한국생화학회지
권/호정보
1992년|25권 8호|pp.696-701 (6 pages)
발행정보
생화학분자생물학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
서지반출

기타언어초록

The action of snake venoms from 3 different kinds of Korean venomous species (Agkistrodon halys brevicaudus, Agkistrodon saxatilis, Agkistrodon ussuriensis) on the haemostasis and fibrinolytic system was studied and compared with other two venoms of Agkistrodon rhodostoma, Malayan Pit Viper and Agkistrodon halys blomhoffi, Japanese Mamushi. The coagulation activity, fibrinolytic, fibrinogenolytic, and amidolytic activity were determined. Fibrinogen clotting activity in the venoms of Agkistrodon saxatilis and Agkistrodon ussuriensis were 1.0 and 3.5 NIH U/mg. However, it was not able to detect the fibrinogen clotting activity from. the venom of Agkistrodon halys (Korean Salmosa) during prolonged incubation. Polyacrylamide gel electrophoretic patterns of these venoms were quite different from each other. After removal of SDS from the gel with Triton X-100, the fibrinolytic activities in the gel could be directly detected by the fibrin-agar zymographic assay method. The venom of Agkistrodon halys has shown at least two distinct fibrinolytic enzymes (51 Kd and 33 Kd, Agkistrodon saxatilis has three (47 Kd, 33 Kd, and 28 Kd), and Agkistrodon caliginosus has two (38 Kd and 33 Kd). No plasminogen activation activity was observed in any of the venoms of Korean poisonous snakes.