LBD-007, a newly developed recombinant human interferon alphaA, was at dose levels of 0, 3$ imes$$10^6$, 6$ imes$ $10^6$ and 12$ imes$1$10^6$ IU/kg/day administered subcutaneously to Sprague-Dawley male rats from premating to mating period and to females from premating to early gestation period. Effects of test agent on reproductive performance of both sexes and embryonic development were examined. 1. No treatment-relared changes in food consumption, body weight and necropsy findings were observed in parent animals.