In this study, reach boundaries in QUAL2E Model were set by the locations of point-waste discharge or tributary input and measured or direct calculated hydrologic factors were used in computation as much as possible. South Platte Experimental River in Colorado, USA was selected as a target river and data collected during September 1991 and January 1992 periods were used for calibration and verification, respectively. Constituents modeled in this study are 5-day carbonaceous biochemical oxygen demand(CBOD$) and dissolved oxygen(DO). The good agreement was obtained between a calculated using this model and observed, less than 5% to DO and about 20% to CBOD$. According to the result of water-quality prediction, experimental river is classified as the 4th category by the criteria of environmental protection agency in the USA in 2001.