To determine the optimal application level of fertilizers, nitrogen, phosphate, potassium and lime in ramie(Beohmeria nivia Hooker et Arnot), the experiments were conducted for four years from seedling stage propagated by suckers to fully-grown stage under various comibinations of $N, P_2O_5, O$ and lime. Increasing in application rate of N and $K_2$O enhanced stem growth of ramie greatly, and it appeared that lime application also had large effect on increase of stem growth. Yield increased greatly by increasing of application rate with two or three times in N and two times in $K_2$O as much as the standard application rate of fertilizers N-$P_2O_5$-$K_2$O =9-3-9kg/l0a. Especially, treatment with 18kg N, 3kg $P_2O_5, $, 18kg $K_2$O and 200kg lime per l0a showed higher percentage of productive culm and increased yield of crude fiber about 33%. The variation among treatments was relatively small in stem length but larger in fresh weight of shoot and stem. The variation was large at early stage of experiment, that is, from one to two years after planting, but decreased progressively from three years after planting. There was no large difference in number of stems among application rates of fertilizers from three years after planting which was fully-grown stage. However, increasing in application rate of Nand $K_2$O twice as much as the standard rate had large effect on increasing the percentage of productive culm, and hence increased yield greatly.