We focus on a way of combining the Monte Calro methods of antithetic variates and control variates to reduce the variance of the estimator of the mean response in a simulation experiment. Combined Method applies antithetic variates (partially) for driving approiate stochastic model components to reduce the vaiance of estimator and utilizes the correlations between the response and control variates. We obtain the variance of the estimator for the response analytically and compare Combined Method with control variates method. We explore the efficiency of this method in reducing the variance of the estimator through the port operations model. Combined Method shows a better performance in reducing the variance of estimator than methods of antithetic variates and control variates in the range from 6% to 8%. The marginal efficiency gain of this method is modest for the example considered. When the effective set of control variates is small, the marginal efficiency gain may increase. Though these results are from the limited experiments, Combined Method could profitably be applied to large-scale simulation models.