This study presents the nonlinear dynamic analysis method of the bridge with the seismic isolation bearing. Also the numerical analyses are performed for investigating the response characteristics of the bridge isolated with the lead-rubber bearing under the ground motions compatible to Korea bridge design response spectra. It is found that the pier design force can be considerably smaller than the one for the bridge with the fixed bearing. It is observed that the lead-rubber bearing has the great effectiveness for reducing the longitudinal seismic force in case of the bridges with low and medium periods. Therefore the seismic isolation bearing can be used instead of the fixed bearing for the economic and safe design of the bridge.