The prediction of crosstalk in one of important problems in estimating the EMC of a system for high speed digital signal transmission. Crosstalk curves are shown in terms of characteristic impedance of lines spacing between lines and rise time of pulse by using general multiple coupled transmission line equation and harmonic-balance method. The coupled symmetrical two-line on dielectric material epoxy-glass FR 4(${varepsilon}_r$), is fabricated to measure crosstalk occuring at the near end and far end of the passive line. The inter-line is inserted to reduce crosstalk between two microstrip lines. The simulation results and the measurement results are shown and found to be very close.