Many vehicle routing methods have been suggested, which minimize the routing distances of vehicles to reduce the total transportation cost. In describing a distribution network, we have stated that it is basically a system or a set of locations that, receive or store material plus the routes that connect these locations. Whether the network is spread over some geographic region or is whitin a single facility, the definition remains the same. Implicit in this definition, however, is that both the locations and the transportation between these locations must be considered in any decisions regarding the design of the operation of the overall network. The purpose of this paper is optimal layout using transportation quantity and distance in the total system operation. And we minimize the sum of load-carrier costs and spur costs in this flow network.