The analysis and tests of thin-walled channel frames including nonlinear flexible or semi-rigid connection behaviour is presented. The semi-rigid connection behaviour is modelled using a mathematical approximation of the connection flexibility-moment relationship. Local instability such as local buckling and torsional flexural buckling of the member are included in the analysis. The full response of the frame, up to the collapse load, can be predicted. Experimental investigation was carried out on a series of simple double storey symmetrical frames with the purpose of verifying the accuracy and validity of the analysis. Agreement between the theoretical and experimental results is acceptable. The investigation also shows that connection flexibility and local instability such as local buckling and torsional flexural buckling can affect the behaviour and strength of thin-walled frames significantly. The results can also provide further insight into the advanced study of practical structures where interaction between flexible connections and phenomenon associated with thin-walled members are present.