The Artificial Intelligence Lab of Industrial Engineering Department, Korea University is continuing to develop expert systems for quality control methods such as acceptance control, process control and reliability analysis. As a series of these efforts, The Artificial Intelligence Lab of Industrial Engineering Department, Korea University is continuing to develop expert systems for quality control methods such as acceptance control, process control and reliability analysis. As a series of these efforts, this paper concerns an expert system for design of experiment. The system includes factorial experiments, response surface methodology and Taguchi method. PROLOG is used as a language with dBASE III＋ for the data base management system and C for calculations and graphics. This system selecting the appropriate method and analyzing the data obtained can be implemented on an IBM PC 386 or a higher level machine.