98종의 한국산버섯의 그람음성균에 대한 항균활성을 검색한 결과 20종의 버섯의 80% 에탄올(E) 및 증류수(H) 추출물이 Klebsiella pneumoniae, Proteus mirabilis, Serratia marcescens, Shiegella sonnei, Shiegella dysenteiae, Salmonella typhi, Salmonella typhimurium 및 Pseudomonas aeruginosa에 대하여 항균력을 나타내며, 특히 R. sinuatus, S. luteus, B. umbriniporus, 그리고 A. tabescens의 E 추출물은 다른 버섯에 비하여 여러 종류의 그람음성균에 대하여 다양한 항균활성을 보였다. Abortiporus biennis, Phellinus gilvus, 및 Polyporus dispansus의 E 추출물은 S. typhi에 대하여 강력한 항균력을 나타내었으며 이들의 MIC는 $10;{mu}g/ml$이었다. 25종 버섯의 곰팡이균에 대한 항균활성을 검색한 결과 Armillariella tabescens의 E 추출물이 Trichopyton mentagrophytes에 대하여 항균력을 가지며 이의 MIC는 $300;{mu}g/ml$이었다.
For the development of antibiotics from Korean mushrooms, the biological activities of extracts from 98 species of mushrooms and from 25 mushrooms were tested against 9 different Gram-negative bacteria and 8 fungi, respectively. Fruiting bodies of each mushrooms were extracted with petroleum ether (P), 80% ethanol (E), and distilled water (H) in that order. P, E, or H extracts from 20 mushroom samples exhibited the antibacterial activity against 8 different Gram-negative bacteria containing Klebsiella pneumoniae, selectively. Among the mushroom extracts with antibiotic activity, E extracts of Boletus umbriniporus, Armillariella tabescens, Rhodophyllus sinuatus, and Suillus luteus showed various antibiotic activities against several bacteria. E extracts of Abortiporus biennis, Phellinus gilvus, and Polyporus dispansus are highly active against Salmonella typhi and their minimum inhibitory concentration (MIC) was all $10;{mu}g/ml$. E extract of Armillariella tabescens showed the antifungal activity against Trichopyton mentagrophytes, and its MIC was $300;{mu}g/ml$.
