In this study, the effects of Boshimdan, which is used in oriental medicine for the treatment of palpitation, chest discomfort, impatience, insomnia, forgetfulness ete., were tested as a part of series of experimental verification of prescriptions treatments for preventing and curing ischemic heart. The results were as follows: 1. Boshimdan did not effectively work on heart rate of the perfused rat heart. 2. Boshimdan did not effectively work on heart pressure of the perfused rat heart. 3. Boshimdan did not effectively work on flow rate of the perfused rat heart. 4. Boshimdan was not effective in activation of GOT. 5. Boshimdan was not effective in activation of GPT. 6. Boshimdan was not effective in activation of LDH. 7. Boshimdan was not effective in activation of CPK.